A polysaccharide composition inhibiting trpv1 pathway and its preparation method and application

A technology of composition and polysaccharide, which is applied in the field of polysaccharide composition inhibiting TRPV1 pathway and its preparation, can solve the problems of ineffective effect, complicated pathogenesis, aggravated allergies, etc., and achieve the effect of pre-protection and repair of skin nerve barrier

Active Publication Date: 2021-11-30
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex pathogenesis of sensitive skin, the current clinical dermatology mainly uses physical, drug and anti-allergic cosmetics for treatment, but the effect is not obvious. In addition, there are many types of cosmetics, and improper use will aggravate allergies

Method used

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  • A polysaccharide composition inhibiting trpv1 pathway and its preparation method and application
  • A polysaccharide composition inhibiting trpv1 pathway and its preparation method and application
  • A polysaccharide composition inhibiting trpv1 pathway and its preparation method and application

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Experimental program
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Effect test

Embodiment 1-5

[0040] Embodiment 1-5: polysaccharide composition of the present invention

Embodiment 1

[0042] Take 1g each of the above-mentioned snow lotus polysaccharides, white fungus polysaccharides, dendrobium polysaccharides, and salvia miltiorrhiza polysaccharide powders, dissolve them in distilled pure water, stir and dissolve thoroughly, and obtain an aqueous solution containing snow lotus polysaccharides, white fungus polysaccharides, and red sage polysaccharides. Among them, the final concentrations of Tianshan Saussurea polysaccharide, Tremella polysaccharide, Dendrobium polysaccharide and Salvia miltiorrhiza polysaccharide were each 0.25 mg / mL.

Embodiment 2

[0044] Take 0.4g each of the above-mentioned Snow Lotus polysaccharides, tremella polysaccharides, dendrobium polysaccharides, and 4 g of Danshen polysaccharides, dissolve them in distilled pure water, stir and dissolve fully, and obtain an aqueous solution containing Tianshan Snow Lotus polysaccharides, Tremella polysaccharides, and Danshen polysaccharides. Among them, the final concentrations of Tianshan snow lotus polysaccharide, Tremella polysaccharide, Dendrobium polysaccharide and Danshen polysaccharide were 0.0077mg / mL, 0.0077mg / mL, 0.0077mg / mL, and 0.077mg / mL.

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Abstract

The invention relates to the technical field of medicines and cosmetics, and discloses a polysaccharide composition for inhibiting TRPV1 pathway, a preparation method and application thereof. The polysaccharide composition of the present invention includes Saussurea sauraceae polysaccharide, Tremella polysaccharide, Dendrobium polysaccharide and Salvia miltiorrhiza polysaccharide; wherein, the concentration of Saussurea sauraceae polysaccharide is not higher than 0.4mg / mL, and the concentration of Dendrobium polysaccharide is not higher than 0.35mg / mL, The concentration of the tremella polysaccharide is not higher than 0.2 mg / mL, and the concentration of the salvia miltiorrhiza polysaccharide is not higher than 0.2 mg / mL. The polysaccharide composition of the present invention can effectively inhibit the expression of TRPV1 pathway, thereby pre-protecting and repairing the skin nerve barrier, and can be used in the prevention and treatment of skin allergies and the preparation of related cosmetics and medicines.

Description

technical field [0001] The invention relates to the technical field of medicines and cosmetics, in particular to a polysaccharide composition for inhibiting TRPV1 pathway, its preparation method and application. Background technique [0002] With the rapid development of social economy and the continuous improvement of residents' living standards, factors such as environmental pollution and life pressure have led to a series of skin problems, such as sensitive skin. According to incomplete statistics, there are more and more people with sensitive skin in the world, of which 38% are men and 61% are women. Environmental pollution and excessive use of cosmetics have gradually weakened the body's resistance to foreign stimulation, and skin allergies and irritations have become more frequent. Common symptoms of skin allergies mainly include redness and itching, and may also be accompanied by symptoms such as blisters, redness, swelling, dryness, and liquefaction. The specific sy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P17/00A61P37/08A61K8/73A61Q19/00C08B37/00
CPCA61K8/73A61K31/715A61K2800/5922A61Q19/005A61P17/00A61P37/08C08B37/0003C08B37/006A61K2300/00
Inventor 杨凯业李莉楠刘光荣杜志云彭奕林丽
Owner INFINITUS (CHINA) CO LTD
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