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Modified compound of marine antibiotic and application thereof

A compound and antibacterial technology, which is applied in the field of modified compounds of marine antibiotics, can solve problems such as penicillin resistance, and achieve the effects of small cytotoxicity, excellent antibacterial activity, and strong antibacterial ability

Pending Publication Date: 2021-01-08
JASAN BIO MEDICINE JIAXING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the widespread use of penicillin, some Staphylococcus aureus produce penicillinase, which can hydrolyze the β-lactam ring, showing resistance to penicillin

Method used

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  • Modified compound of marine antibiotic and application thereof
  • Modified compound of marine antibiotic and application thereof
  • Modified compound of marine antibiotic and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A natural fungicidal compound was purified from the marine fungus StachybotryspMF347, alcoholic extract with the following formula:

[0015]

[0016] Compound (I) is obtained through its structural modification.

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PUM

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Abstract

The invention relates to the field of antibiotics, in particular to a modified compound of a marine antibiotic and application thereof. The compound is shown as formula (I) in the specification, and the compound (I) has antibacterial ability. The modified compound of a marine antibiotic has strong antibacterial ability on methicillin-resistant staphylococcus aureus, has excellent antibacterial activity, and has low cytotoxicity.

Description

technical field [0001] The invention relates to the field of antibiotics, in particular to a modified compound of marine antibiotics and its application. Background technique [0002] Methicillin-resistant Staphylococcus aureus is a clinically common and highly toxic bacterium. Since the advent of penicillin in the 1940s, infectious diseases caused by Staphylococcus aureus have been largely controlled. However, with the widespread use of penicillin, some Staphylococcus aureus produce penicillinase, which can hydrolyze the β-lactam ring, showing resistance to penicillin. Scientists have developed a new semi-synthetic penicillin that is resistant to penicillinase, namely methicillin. [0003] After it was applied clinically in 1959, it effectively controlled the infection of Staphylococcus aureus enzyme-producing strains, but Jevons in the United Kingdom discovered methicillin-resistant Staphylococcus aureus (MRSA) for the first time. Since the discovery of MRSA, the infectio...

Claims

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Application Information

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IPC IPC(8): C07C47/565A61P31/04A61K31/11
CPCC07C47/565A61P31/04
Inventor 管燕贺耘陆建军
Owner JASAN BIO MEDICINE JIAXING CO LTD