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Harmonic amplitude-temperature method for magnetic nanoparticle temperature measurement in high-frequency excitation magnetic field

A technology of magnetic nanoparticles and harmonic amplitude, which is applied in the field of non-invasive temperature measurement, can solve the problems of not being suitable for high-frequency excitation magnetic fields, and being unable to build harmonic models

Active Publication Date: 2021-01-12
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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Problems solved by technology

[0004] Aiming at the technical bottleneck that it is difficult to measure the temperature of magnetic nanometers under high-frequency excitation magnetic field, and the influence of relaxation phenomenon under high-frequency magnetic field excitation on the harmonic amplitude information of the magnetization response, the Fokker-Planck equation can accurately describe the AC magnetization dynamics (mainly composed of Neil rotation relaxation) but cannot build a harmonic model, and the Langevin equation can build a harmonic model, but it is not suitable for the technical problems of the high-frequency excitation magnetic field. The invention proposes a harmonic model for temperature measurement of magnetic nanoparticles in a high-frequency excitation magnetic field. The amplitude-temperature method, by analyzing the AC magnetization difference between the Fokker-Planck equation and the Langevin equation, and according to the dependence of the magnetization response harmonic amplitude and phase lag on the excitation magnetic field strength, a A simple empirical harmonic model, and then proposed a harmonic amplitude-temperature model for magnetic nanoparticle temperature measurement under the action of Neil relaxation in the high-frequency excitation magnetic field; the present invention enables the method of temperature measurement in the high-frequency AC excitation magnetic field It is possible to overcome the limitation that magnetic nanometer temperature measurement can only be used in low-frequency excitation magnetic fields, and it is expected to meet the requirements of high-precision real-time temperature measurement in industrial and medical fields, expand the measurement range of magnetic nanometer temperature measurement and magnetic nanoimaging, and improve the measurement precision

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  • Harmonic amplitude-temperature method for magnetic nanoparticle temperature measurement in high-frequency excitation magnetic field

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experiment example 1

[0102] 1. Experimental conditions

[0103] In order to study the effectiveness and feasibility of the present invention, the dependence of the harmonic and phase lag of the magnetization response information affected by Neel relaxation on the excitation magnetic field strength was studied. In the experiment, a commercially available magnetic nanoparticle sample SHP-20 (Ocean Nanotechnology, Inc., USA) was used. SHP-20 is an iron oxide nanoparticle having a carboxylic acid group, and the iron concentration of SHP-20 is 5 mg(Fe) / mL. The magnetic nanoparticle samples were fixed with epoxy resin to avoid the influence of Brownian relaxation. During the fixation process, the magnetic nanoparticle samples were placed on a DC excitation magnetic field with a strength of 50 mT to ensure that the easy magnetization axes of all magnetic nanoparticles were along the same direction.

[0104] The saturation magnetization (211kA / m) of the magnetic nanoparticle sample was measured under a ...

experiment example 2

[0108] 1. Experimental conditions

[0109] The magnetization of the magnetic nanoparticle sample was calculated using the Langevin equation and the harmonic amplitude A was obtained using DPSD 2j-1 . The experimental conditions are the same as the experimental case one. Therefore, G associated with the strength of the excited magnetic field can be obtained 2j-1 =C 2j-1 / A 2j-1 .

[0110] 2. Experimental test results

[0111] Figure 8 Representing the compensation function G of different harmonics of the magnetic nanoparticle sample SHP-20 2j-1 , the symbol is G 2j-1 The experimental data of , the solid line represents G 2j-1 Polynomial fit results. For the SHP-20 sample, the compensation function G for different harmonics 2j-1 The dependence on the excitation magnetic field is different. The first harmonic and the third harmonic decrease with the increase of the excitation magnetic field strength; the third harmonic shows a rapid decrease with the increase of the ...

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Abstract

The invention provides a harmonic amplitude temperature measurement method for magnetic nanoparticle temperature measurement in a high-frequency excitation magnetic field, and the method comprises thesteps: carrying out the fitting of a harmonic amplitude compensation function through a Fokker-Planck equation and a Langevin equation, and building a harmonic amplitude-temperature model for magnetic nanoparticle temperature measurement in the high-frequency excitation magnetic field; and substituting the harmonic amplitude and the phase information of the magnetic nano sample under the high-frequency excitation magnetic field into the constructed harmonic amplitude-temperature model, and solving the temperature information of the magnetic nano sample. According to the invention, magnetic nano real-time temperature measurement in a high-frequency excitation magnetic field is realized, the problem that a magnetic nano temperature measurement method is only suitable for a low-frequency excitation magnetic field and cannot be applied to a high-frequency magnetic field is solved, and the timeliness and feasibility of magnetic nano particles are improved; the method can be used for solving the problem of low magnetic nano temperature measurement precision under high-frequency magnetic field excitation of high-power integrated devices in the industrial field and thermal therapy in themedical field.

Description

technical field [0001] The invention relates to the technical field of non-invasive temperature measurement, in particular to a harmonic amplitude-temperature method for temperature measurement of magnetic nanoparticles in a high-frequency excitation magnetic field, which solves the problem that magnetic nanometer temperature measurement or magnetic nanoimaging technology is not suitable for high The bottleneck of frequency excitation has expanded the application field and scope of magnetic nanometer temperature measurement. Background technique [0002] Magnetic nanoparticles have been widely used in industrial and biomedical fields, among which magnetic nanoparticle-mediated hyperthermia is a new type of cancer treatment method, which is based on the difference in heat resistance between tumor tissue and normal tissue, through physical Methods Local heating kills cancer cells, and the window temperature of tumor hyperthermia is 315K-319K (42°C-46°C). The non-invasiveness ...

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Application Information

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IPC IPC(8): G01K7/38
CPCG01K7/38G01K2211/00
Inventor 杜中州叶娜孙毅王丹丹苏日建
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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