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Selection and use of melatonin supporting bacteria to reduce infantile colic

A melatonin, baby technology, applied in bacteria, medical raw materials derived from bacteria, enzymes, etc., can solve problems such as frequent recommendation

Active Publication Date: 2021-01-15
BIOGAIA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although several studies have demonstrated that simethicone is no better than placebo for infant colic, simethicone has a safety profile and is frequently recommended

Method used

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  • Selection and use of melatonin supporting bacteria to reduce infantile colic
  • Selection and use of melatonin supporting bacteria to reduce infantile colic
  • Selection and use of melatonin supporting bacteria to reduce infantile colic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0186] Method for identifying strains with genes encoding cell surface localized 5'-nucleotidases

[0187] Bacteria were grown on MRS plates for 16 h at 37 °C in an anaerobic atmosphere. Ten bacterial colonies were collected with a sterile plastic loop and suspended in 100 microliters of sterile water (PCR quality). (Alternative: prepare DNA from bacterial culture using a suitable method).

[0188] The presence of the 5'-nucleotidase gene can be checked by PCR, for example by using PuReTaq Ready ToGo PCR beads (GE HealthCare) and either of the primer pairs described below (0.4 mM each). The bacterial suspension or DNA preparation (0.5 µl) should be added to the PCR mix and the PCR reaction should be performed by running the following program: 95 °C, 5 min; 30x (95 °C, 30 sec; 55 °C, 30 sec; 72°C, 30 seconds); 72°C, 10 minutes. PCR products can be separated and visualized by using standard agarose gel electrophoresis and sequenced by standard Sanger sequencing (using the for...

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Abstract

The present invention relates to lactic acid bacterial strains which are capable of producing or inducing the production of melatonin, for use in the production of melatonin in a subject. Preferred strains for such uses are capable of producing or inducing the production of adenosine. Therapeutic uses of such strains include the treatment or prevention of diseases associated with melatonin deficiency, for example infantile colic. Novel strains are also provided.

Description

[0001] field of invention [0002] The invention herein provides certain strains of lactic acid bacteria, methods of selecting such strains, and products containing such strains for use in the prevention and / or treatment of colic (or in combination with melatonin) for their increased melatonin levels. other diseases associated with decreased levels of melatonin), including the ability to produce melatonin precursors and other important components for melatonin release. Furthermore, the present invention relates to formulations comprising substrate components specifically selected to enhance the efficacy of such strains. [0003] Background of the invention [0004] Despite its prominence in terms of both prevalence and distress, infantile colic remains poorly understood about its nature and causes. There are also different terms used to describe the condition. These terms include "infant colic," "night colic" (because the pain is mostly confined to the night), and "trimester ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20C12P19/40C12P17/16A61K35/74A61P1/00A61P5/00A61P25/28A61P25/20C12R1/225
CPCC12N1/205C12P17/165C12P19/40A61K35/747A61P1/00A61P25/28A61P5/00A61K35/74C12R2001/225C12Y301/03031C12N1/20C12N9/16
Inventor S·鲁斯B·莫利斯塔姆
Owner BIOGAIA AB