Method for preparing cannabidiol by decarboxylation of cannabidiolic acid in industrial hemp

A technology of cannabidiolic acid and cannabidiol, which is applied in the field of extraction and purification of plant components and achieves the effects of low operating temperature, high efficiency and less peculiar smell

Pending Publication Date: 2021-01-26
DAQING BRANCH OF HEILONGJIANG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of decarboxylation and conversion of cannabidiolic acid in actual work, develop the active ingredients of cannabinoids in industrial hemp, and provide a method for preparing cannabidiol by decarboxyl

Method used

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  • Method for preparing cannabidiol by decarboxylation of cannabidiolic acid in industrial hemp
  • Method for preparing cannabidiol by decarboxylation of cannabidiolic acid in industrial hemp
  • Method for preparing cannabidiol by decarboxylation of cannabidiolic acid in industrial hemp

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Embodiment 1

[0026] A method for preparing cannabidiol from cannabidiolic acid decarboxylation in industrial hemp, the method being specifically:

[0027] Step 1: Processing of industrial hemp flowers and leaves: Harvest industrial hemp flowers and leaves at maturity, wash and remove impurities, then dry at natural temperature, crush, pack, and store at low temperature for later use; the function of this pretreatment step is to clean Clean is conducive to the uniform transmission of microwave radiation cracking energy;

[0028] Step 2: Microwave radiation cannabidiolic acid decarboxylation method: Weigh 100g of the processed industrial hemp mosaic leaf sample and put it into a 1L raw material kettle. The experimental parameters are set to microwave radiation temperature of 40°C, microwave power of 300W, and time of 30 minutes.

[0029] Detect the content of cannabidiol: the specific chromatographic conditions are: chromatographic column: C18 (150mm×4.6mm, 5μm); mobile phase: nitrile-water ...

Embodiment 2

[0031] The difference between this embodiment and the embodiment 1 is that in the second step, the experimental parameters are set as the microwave radiation temperature of 40° C., the microwave power of 450 W, and the time of 30 minutes.

Embodiment 3

[0033] The difference between this embodiment and the embodiment 1 is that in the second step, the experimental parameters are set as the microwave radiation temperature of 40° C., the microwave power of 600 W, and the time of 30 minutes.

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Abstract

The invention discloses a preparation method for decarboxylating cannabidiolic acid in industrial hemp, belongs to the technical field of plant component extraction and purification, and particularlyrelates to a pretreatment process method for preparing cannabidiol by decarboxylating cannabidiolic acid. A microwave radiation method is used for converting cannabidiolic acid into cannabidiol through cannabidiol acid decarboxylation. The optimal decarboxylation conditions are as follows: the microwave radiation temperature is 60 DEG C, the microwave power is 600W, the microwave radiation time is30 minutes. The decarboxylation rate of the cannabidiol acid is 98 percent or more through liquid chromatography analysis, the conversion rate of the cannabidiolic acid into the cannabidiol is 99 percent, and the cannabidiol structure is analyzed through mass spectrometry. The microwave radiation method is adopted for cannabidiolic acid decarboxylation, cannabidiol can be simply and efficiently obtained through convertion, compared with a heating decarboxylation method, the method has the advantages of being short in time, high in efficiency, low in energy consumption, small in environmentalpollution and the like, and the method is suitable for raw material pretreatment in the pharmaceutical field and industrial production.

Description

technical field [0001] The invention belongs to the technical field of extraction and purification of plant components, and in particular relates to a method for preparing cannabidiol by decarboxylation of cannabidiolic acid in industrial hemp. Background technique [0002] Cannabis (Cannabis sativa L.) belongs to Magnolia, Urtica, Cannabis, Cannabis, Cannabis species, and is an annual herb. Cannabis is the most controversial plant in the world, the main neutral component of which is (-)-trans-Δ 9 - THC (Δ 9 -THC) can cause hallucinogenic effects and is therefore required to be strictly regulated. Cannabis plants are widely distributed all over the world. In recent years, with the continuous in-depth excavation of hemp plant resources, they have been used in textiles, papermaking, composite materials, medicine and other fields. Internationally, hemp with a tetrahydrocannabinol (THC) content of less than 0.3% is called industrial hemp. In my country, industrial hemp is als...

Claims

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Application Information

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IPC IPC(8): C07C37/68C07C37/50C07C39/23C07C51/42C07C51/47C07C65/19
CPCC07C37/004C07C37/685C07C37/50C07C39/23C07C51/42C07C51/47C07C65/19C07C2601/16
Inventor 高宝昌孙宇峰田媛石雨张旭崔宝玉梅雪松马雪松
Owner DAQING BRANCH OF HEILONGJIANG ACAD OF SCI
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