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Ophthalmic polymeric materials, making method, and use thereof

A kind of polymer material and polymer technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of whitening, low flash point, high water content, etc., to overcome the whitening phenomenon and high water content Effect

Active Publication Date: 2021-01-29
康小林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The material proposed by the present invention not only has the advantages of no flash point and no whitening phenomenon of hydrophilic materials, but also has the advantages of low water content, no calcium deposition and no need for hydration of hydrophobic materials, and overcomes the calcium deposition of hydrophilic materials, The shortcomings of high PCO and the need for hydration, overcome the shortcomings of other hydrophobic materials that have flash points and white surfaces, and overcome the current market or patent materials that have reduced flash points but high water content and whitening The problem of phenomena

Method used

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  • Ophthalmic polymeric materials, making method, and use thereof
  • Ophthalmic polymeric materials, making method, and use thereof
  • Ophthalmic polymeric materials, making method, and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0090] The preparation of embodiment 1 polymer P1

[0091] Mix HEMA (5 g), DEOPOMA (31 g), PEA (42 g), PEMA (22 g), BDDA (2.5 g), EGDMA (2.5 g), Uv-01 (2 g), and P16 (0.05 g) well, then transfer Put it into a cavity mold made of glass or polypropylene or polytetrafluoroethylene (cavity diameter 15mm, height 15cm), and then put it in an oven at 100±2°C for 24 hours to obtain a transparent and elastic polymer. The resulting polymer is removed by Soxhlet extraction with ethanol to remove residual monomers or oligomers, and then dried in vacuum at 60°C±2°C for 24 hours, and then the material is processed into specifications with a central thickness of 0.7mm, an edge thickness of 0.30mm, and a diameter of Intraocular lens with a diameter of 6mm and a radius of curvature of 18mm.

Embodiment 2-5

[0092] The preparation of embodiment 2-5 polymer P2, P3, P4, P5 and P6

[0093] The preparation method of polymers P2, P3, P4 and P6 is the same as that of P1, and the quality composition of each formula is shown in Table 1.

Embodiment 7

[0094] The preparation method of embodiment 7 polymer P7

[0095] MOHEMA(8g), MOHEA(2g), POHEA(2g), PEG1000MA(5g), EA(23g), PEA(60g), TMPTA(4g), Uv-02(1.5g), P16(0.05g), TPO (0.05g) and DMNMA (0.05g) are mixed evenly, and then the mixture is transferred to a cavity mold made of glass or polypropylene or Teflon (cavity diameter 15mm, height 15cm), and then a 4.8Kw high-pressure mercury lamp After irradiating for 2 minutes, put it into an oven at 100±2°C and keep it warm for 10 hours to obtain a transparent and elastic polymer. The resulting polymer was removed by Soxhlet extraction with ethanol to remove residual monomers or oligomers, then dried in vacuum at 60±2°C for 24 hours, and then the material was processed into specifications with a central thickness of 0.67mm, an edge thickness of 0.27mm, and a diameter of IOL lens with 6mm and 18mm radius of curvature.

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Abstract

The invention provides an ophthalmic medical material, which is a hydrophobic polymer material with no flash point, no surface whitening, no calcium deposition and water content not higher than 1.5%,and is a medical implant material suitable for treating cataract, myopia and hyperopia.

Description

technical field [0001] The invention relates to an ophthalmic medical material, in particular to a hydrophobic intraocular lens material with no flash point, no surface whitishness, no calcium deposition and a water content mass fraction not higher than 1.5%, which is suitable for treating cataract, Medical implant materials such as myopia and hyperopia. Background technique [0002] The current method of treating cataract is to use intraocular lens to replace the turbid natural lens through surgical implantation. At present, commonly used materials are divided into hydrophilic materials and hydrophobic materials. Among them, hydrophilic materials need to be packaged in a hydrated state and subjected to high-pressure steam sterilization for use; Hydrophobic materials do not need to be hydrated. They are packaged in a dry state and sterilized with ethylene oxide before use. Hydrophobic materials do not need to be hydrated before use. [0003] Hydrophilic materials or hydroph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/30C08F220/18C08F222/14C08F220/34C08F220/20A61L27/16
CPCC08F220/301C08F220/1802A61L27/16A61L2430/16C08F220/1804C08F222/102C08F222/103C08F220/34C08F220/20C08L33/14
Inventor 康小林
Owner 康小林
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