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A kind of transdermal drop for animal deworming and preparation method thereof

A technology of transdermal agent and transdermal enhancer, applied in the field of animal anthelmintic agents, can solve the problems of stimulating the respiratory mucosa of pet breeders, strong skin irritation of the preparation, and animal rejection of drugs, etc., so as to achieve non-irritating respiratory mucosa, Improves bactericidal properties and promotes absorption

Active Publication Date: 2022-03-11
宁波科瑞特动物药业有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these preparations can meet the drug needs of animals to varying degrees, there are still shortcomings such as inconvenient route of administration, large first-pass effect, strong skin irritation of the preparation, and strong pungent smell, which will cause animals to be sensitive to the drug. exclusion
If the irritating smell of the preparation is severe, when the preparation is applied to pets, it will irritate the respiratory mucosa of the pet breeder and cause certain harm to the pet breeder

Method used

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  • A kind of transdermal drop for animal deworming and preparation method thereof

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preparation example Construction

[0050] A second aspect of the present invention provides a method for preparing transdermal drops for animal deworming, at least comprising the following steps:

[0051] (1) Mixing the macrolide compound with a cosolvent to obtain a mixture A;

[0052] (2) Add organic solvent, antioxidant, transdermal agent, transdermal accelerator to mixture A to obtain mixture B;

[0053] (3) Add emulsifier to mixture B.

[0054] A third aspect of the present invention provides a method of using transdermal drops for animal deworming. The method of use for livestock is: pouring from the shoulders of livestock backwards along the midline of the back; the method of use for pets is: Rub from the inside of the pet's ears or pour from the shoulders back along the midline of the back.

[0055] In addition, all raw materials used are commercially available unless otherwise stated.

Embodiment 1

[0057] In order to solve the above technical problems, the first aspect of this embodiment provides a transdermal drop for animal repellent, in parts by weight, its preparation raw materials include 0.5 part of macrolide compound, transdermal agent 3 parts, 10 parts of skin penetration enhancer, 40 parts of solvent, 15 parts of emulsifier and 0.02 part of antioxidant, and described solvent comprises organic solvent and auxiliary solvent. Domestic animals in this embodiment include horses, cows, sheep, mules, donkeys, foxes, pigs, chickens, ducks, geese, and pigeons, and pets include dogs, cats, and rabbits. The macrolide compound is abamectin, which is purchased from Zhengzhou Yuancheng Biotechnology Co., Ltd., CAS number: 71751, model: 241588.

[0058] The transdermal agent is azone, which is purchased from Shaanxi Tengmai Biotechnology Co., Ltd., with a CAS number of 59227-89-3 and a product number of 002.

[0059] The skin penetration enhancer is a mixture of propylene gly...

Embodiment 2

[0072] In order to solve the above technical problems, the first aspect of this embodiment provides a transdermal drop for animal repellent, in parts by weight, its preparation raw materials include 0.75 parts of macrolide compound, transdermal agent 4 parts, 15 parts of skin penetration enhancer, 55 parts of solvent, 22 parts of emulsifier and 0.05 part of antioxidant, and described solvent comprises organic solvent and auxiliary solvent. Domestic animals in this embodiment include horses, cows, sheep, mules, donkeys, foxes, pigs, chickens, ducks, geese, and pigeons, and pets include dogs, cats, and rabbits. The macrolide compound is abamectin, which is purchased from Zhengzhou Yuancheng Biotechnology Co., Ltd., CAS number: 71751, model: 241588.

[0073]The transdermal agent is azone, which is purchased from Shaanxi Tengmai Biotechnology Co., Ltd., with a CAS number of 59227-89-3 and a product number of 002.

[0074] The skin penetration enhancer is a mixture of propylene gl...

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Abstract

A transdermal drop for animal repellent, in parts by weight, its preparation raw materials include 0.5-1 part of macrolide compound, 3-5 parts of transdermal agent, 10-20 parts of transdermal accelerator, 40-70 parts of solvent, 15-30 parts of emulsifier and 0.02-0.1 part of antioxidant, the solvent includes organic solvent and auxiliary solvent. The present invention also provides a method of using transdermal drops for animal deworming, the method of using livestock is: from the shoulders of livestock backward, pouring along the midline of the back; the method of using pets is: using two ears of pets Apply on the inner side of the ear or pour from the shoulder back along the midline of the back. The transdermal drop in the technical proposal has a good deworming effect on animals and reduces the stress response of animals. A certain amount of alcohols and plant essential oils are used as transdermal accelerators, which can not only promote the absorption of macrolide compounds by the epidermis, but also improve the bactericidal performance of the overall transdermal drops, and have almost no irritation to the epidermis of animals.

Description

technical field [0001] The invention belongs to the field of animal deworming agents, and in particular relates to a transdermal drop for animal deworming and a preparation method thereof. Background technique [0002] With the continuous development of the country's economy and technological level, people's living standards are also constantly improving. As the spiritual companion of human beings, more and more people choose to feed them, especially the number of pet dogs and cats is increasing year by year. For dogs and cats, superficial and internal parasitic diseases have always been a special concern of pet lovers. Parasites not only endanger the health of pets, but also indirectly affect the quality of life of pet owners. Therefore, safe, effective and easy-to-use deworming Medicine is especially popular with pet lovers. Since most of the current conventional anthelmintics are aimed at internal parasites, the effect of expelling and killing external parasites is not o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/365A61K9/00A61K47/10A61K47/44A61K47/14A61K47/22A61P33/10A61P33/14
CPCA61K31/7048A61K31/365A61K9/0046A61K9/0014A61K47/10A61K47/44A61K47/14A61K47/22A61P33/10A61P33/14
Inventor 陈君德王亚佩岳春梅施明华张世忠杜雄伟
Owner 宁波科瑞特动物药业有限公司