Applications of semifluid containing blood cells, vaccine containing semifluid and preparation method of vaccine

A technology of blood cells and semi-fluids, applied in the field of semi-fluids containing blood cells, vaccines containing the semi-fluids and the preparation of the vaccines, to achieve the effects of low immune activity, low graft risk, and high effectiveness against solid tumors

Inactive Publication Date: 2021-02-02
CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The big question remains the same: how can one develop a solid tumor vaccine antigen that has the desired (anti-tumor) antigenicity to be clinically effective without the need for antigenicity (e.g. GVHD) and is clinically safe Inside? Thus, there is still a need to develop new immunization strategies to meet urgent clinical needs that cannot be met by existing technologies

Method used

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  • Applications of semifluid containing blood cells, vaccine containing semifluid and preparation method of vaccine
  • Applications of semifluid containing blood cells, vaccine containing semifluid and preparation method of vaccine
  • Applications of semifluid containing blood cells, vaccine containing semifluid and preparation method of vaccine

Examples

Experimental program
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preparation example Construction

[0121] According to yet another aspect disclosed in the present application, it provides a method for preparing a vaccine for treating or inhibiting solid tumors, the vaccine comprising a semifluid containing blood cells as an antigen, the method comprising the following steps:

[0122] a. providing fluid containing blood cells;

[0123] b. Carry out semi-fluidization treatment to the fluid in step a, wherein said semi-fluidization is selected from one or more of the following: semi-fluid viscosification of liquid, semi-fluid solidification of liquid, non-liquid or solidification broken.

[0124] If involved, the definitions and descriptions of the relevant terms in the foregoing aspects disclosed in the present application are also applicable to this aspect.

[0125] In one embodiment, the step a may include the step of: providing the fluid containing blood cells from natural blood or concentrated blood.

[0126] In one embodiment, the step a may include the following steps...

Embodiment 1

[0163] Embodiment 1: the preparation of vaccine

[0164] In the following examples, the blood cells used are selected from one or more of the following groups:

[0165] 1) Blood cells in the blood. For example, using blood containing the desired blood cells;

[0166] 2) Desired blood cells enriched in the blood fraction. For example, using blood cell-rich blood cells to concentrate blood;

[0167] 3) Natural blood cell preparations and / or engineered blood cells derived from organs and / or tissues rich in blood cells. Natural cell preparations include purified natural cells and their derivatives. For example, cell pellets, leukocyte pellets, red blood cell pellets, platelet pellets obtained from natural blood separations according to the prior art. Another example is hematopoietic stem cells extracted and prepared from bone marrow and other tissues according to the prior art. For another example, through in vitro induction, activation, and expansion of autologous or alloge...

Embodiment 1a

[0177] Example 1a: Kill a New Zealand rabbit and take 15ml of the free blood, and let it stand at room temperature for 30 minutes to obtain self-coagulated blood (X1 in Table 2).

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Abstract

The invention relates to applications of semifluid containing blood cells, a vaccine containing the semifluid, a preparation method of the vaccine and a method for treating or inhibiting solid tumor.

Description

technical field [0001] The present application relates to the use of a semifluid containing blood cells, a vaccine containing it, a method for preparing the vaccine, and a method for treating or inhibiting solid tumors. Background technique [0002] Under the pressure of the body's immune selection, cancer cells often rely on their own high mutation characteristics to gradually establish an immunosuppressive microenvironment to resist and suppress the body's immune recognition and response, and finally show the immune tolerance of the tumor body to the body. The core of solid tumor vaccine development is to develop its safe and effective antigens. Substances with multiple structural levels can be used as vaccine antigens, providing a broad space for vaccine development. [0003] Microorganisms (such as bacteria, viruses, parasites, etc.) were first used as antigens in the development of solid tumor vaccines. Although some microbial live vaccines or inactivated vaccines hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00A61K9/00A61P35/00A61P37/04
CPCA61K9/0019A61K9/0024A61K39/0008A61K2039/515A61K2039/57A61P35/00A61P37/04
Inventor 邹方霖邹礼常王建霞王艺羲
Owner CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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