A kind of preparation method and application of ultrafine uniform acrylamide polymer hydrogel silk

Abstract

The invention relates to a preparation method of ultrafine and uniform acrylamide polymer hydrogel filaments, comprising: configuring a reaction solution of acrylamide polymer under ice bath conditions, and sucking the reaction solution into a polymerization reaction tube through a syringe; The two ends of the polymerization reaction tube are facing upwards, and the parabolic bending is performed; the polymerization reaction tube is suspended for 2h-8h, and the baking reaction is carried out to obtain the acrylamide polymer hydrogel; the polymerization reaction tube is vacuum-dried for 4h-8h to obtain Acrylamide polymer dry filament; the polymerization reaction tube is cut into sections to obtain multiple short polymerization reaction tubes with preset lengths; the acrylamide polymer dry filament is pushed out of the short polymerization reaction tube through a stainless steel wire; purification is carried out in the immersion solution to obtain an acrylamide polymer expansion filament; and to dry naturally to obtain an acrylamide polymer hydrogel filament with a preset outer diameter. The hydrogel filaments prepared by this method are ultrafine and uniform.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a preparation method and application of ultrafine and uniform acrylamide polymer hydrogel filaments. Background technique [0002] Aneurysm is a very common vascular disease, which is caused by the lesion or injury of the arterial wall, resulting in localized or diffuse expansion or bulging of the arterial wall. any part of the system. Once an aneurysm ruptures, serious consequences may result. Such as intracranial aneurysm rupture, resulting in subarachnoid hemorrhage, severe cases can cause vasospasm and large-scale cerebral infarction, resulting in hemiplegia and coma. The current treatment options for aneurysms mainly include open surgery and endovascular intervention. The open surgical treatment plan needs to open the body cavity surrounding the aneurysm, such as craniotomy and thoracotomy, which will cause huge damage to the patient's body, and the postoperative recover...

AI Technical Summary

Problems solved by technology

[0004] The modified coil requires ultra-fine and uniform hydrogel filaments, and it is impossible or difficult to obtain ultra-fine and uniform hydrogel filaments by traditional techniques, because the hydrogel polymer is an inert cross-linked polymer, which is difficult to obtain. It is soluble in any organic solvent, so the drawing process is very difficult. At the same time, because the hydrogel is brittle and brittle after being swollen with water, the breaking force value in the dry state is small, which is also the reason why it is difficult to draw.

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