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Mass analyzer including an ion source and a reaction cell and systems and methods using them

A mass analyzer and reaction cell technology, applied in the field of ion sources, can solve problems such as lack of flexibility

Active Publication Date: 2021-02-02
PERKINELMER HEALTH SCI CANADA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, existing techniques are often inflexible

Method used

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  • Mass analyzer including an ion source and a reaction cell and systems and methods using them
  • Mass analyzer including an ion source and a reaction cell and systems and methods using them
  • Mass analyzer including an ion source and a reaction cell and systems and methods using them

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A sample comprising argon and volatile organic compounds may be introduced into chamber 316 through chamber inlet 340 of mass analyzer 300 . Depending on the voltage and pressure used, the source can provide either intact molecular ions or fragment ions to the downstream reaction cell 370 .

Embodiment 2

[0056] In another mode of operating the mass analyzer, argon itself (eg, through chamber inlet 340 ) can be provided to chamber 316 without any analyte. The generated argon ion beam having an energy distribution of about 12 eV may be directed into reaction cell 370 . The analyte vapor can then be introduced (eg, through inlet 364 ) into the reaction cell at a pressure of 5 to 10 mTorr. Analyte molecules with ionization potentials below 12eV upon collision with argon ions are ionized and remain as intact molecular ions. These ions can be mass separated using a downstream quadrupole mass filter or other mass filter.

Embodiment 3

[0058] A similar setup to that used in Example 2 may be used, but with additional excitation of the argon ions prior to providing them to the downstream reaction cell 370 . The argon ions can be excited to about 40 eV energy before entering the reaction cell 370 where they collide with sample molecules.

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PUM

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Abstract

Certain configurations of a mass analyzer comprising two chambers for ionizing species to form ions and / or introduce a reaction gas to assist in ionization are described. In some instances, a first chamber may receive electrons to permit electron bombardment of a first gas. A second chamber can receive a second gas and the ions from the first chamber to permit the ions and second gas to interact.The first gas or the second gas or both may include analyte.

Description

[0001] priority application [0002] This application is related to, and claims priority and benefit from, U.S. Application No. 15 / 958,781, filed April 20, 2018. technical field [0003] This article relates to mass analysis, and more specifically to ion sources that rely on electron impact ionization and / or chemical ionization. A mass analyzer including an ion source and a reaction cell is described. Background technique [0004] Conventional mass spectrometry techniques rely on the formation of analyte ions for analysis. Numerous ionization techniques - such as electrospray ionization, chemical ionization and electron impact ionization - are known. However, existing techniques often lack flexibility. Therefore, there remains a need for new ionization techniques and devices and mass analyzers that rely on such techniques. Contents of the invention [0005] Certain aspects are described with reference to ion sources and mass analyzers including ion sources and reaction...

Claims

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Application Information

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IPC IPC(8): H01J49/08H01J49/42
CPCH01J49/145H01J49/147H01J49/0077
Inventor H.甘布尔G.贾瓦赫里L.库辛斯C.乔利夫M.斯诺
Owner PERKINELMER HEALTH SCI CANADA INC
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