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A kind of preparation method of improving creatine nitrate yield

A technology of nitrate and creatine, which is applied in the field of creatine preparation, can solve the problems of low yield of creatine nitrate and insufficient reaction process, and achieve the effects of high purity of creatine, avoiding side reactions, and mild reaction process

Active Publication Date: 2022-05-24
湖南天成生化科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned reaction process is not thorough enough, creatine nitrate yield is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of preparation method that can improve creatine nitrate yield, comprises the steps:

[0022] S1, mix 20kg of water, 20kg of activated carbon, and 1kg of phosphatidylcholine, add 40kg of creatine monohydrate and stir at room temperature for 10min, with a stirring speed of 1600r / min, reduce the speed to 100r / min, and continue to stir for 4h to obtain pretreated creatine;

[0023] S2. Stir the pretreated creatine at room temperature, slowly add 15kg of 58% nitric acid solution by mass during the stirring process, and add the nitric acid solution at a rate of 4kg / h. After the addition is complete, continue ultrasonic treatment for 2h, the ultrasonic power is 300W, and the ultrasonic frequency is 20kHz, get the preform;

[0024] S3. Filter the prefabricated material, remove solids, and slowly cool the remaining liquid. First, cool down from room temperature to 15°C at a rate of 1°C / min, let stand for 1 hour, and continue to cool down to 1°C at a rate of 0.2°C / min. It...

Embodiment 2

[0026] A kind of preparation method that can improve creatine nitrate yield, comprises the steps:

[0027] S1, mix 40kg of water, 10kg of activated carbon and 2kg of phosphatidylcholine, add 20kg of creatine monohydrate and stir at room temperature for 20min, the stirring speed is 1200r / min, the speed is reduced to 400r / min, and the stirring is continued for 2h to obtain pretreated creatine;

[0028] S2. Stir the pretreated creatine at room temperature, slowly add 20 kg of 50% nitric acid solution by mass during the stirring process, and add the nitric acid solution at a rate of 10 kg / h. After the addition is complete, continue ultrasonic treatment for 1 h, the ultrasonic power is 400 W, and the ultrasonic frequency is 15kHz, get the preform;

[0029] S3. Filter the prefabricated material, remove solids, and slowly cool the remaining liquid. First, cool down from room temperature to 10°C at a rate of 2°C / min, let stand for 2 hours, and continue to cool down to 5°C at a rate of...

Embodiment 3

[0031] A kind of preparation method that can improve creatine nitrate yield, comprises the steps:

[0032] S1. Mix 25kg of water, 17kg of activated carbon and 1.3kg of phosphatidylcholine, add 35kg of creatine monohydrate and stir at room temperature for 12min, the stirring speed is 1500r / min, the speed is reduced to 200r / min, and the stirring is continued for 3.5h to obtain pretreated muscle acid;

[0033] S2. Stir the pretreated creatine at room temperature, slowly add 16kg of 56% nitric acid solution by mass during the stirring process, and add the nitric acid solution at a rate of 4kg / h. After the addition is complete, continue ultrasonic treatment for 1.7h, the ultrasonic power is 320W, the ultrasonic frequency is 19kHz, and the prefabricated material is obtained;

[0034] S3. Filter the prefabricated material, remove solids, and slowly cool the remaining liquid. First, cool down from room temperature to 13°C at a rate of 1.3°C / min, let stand for 1.3 hours, and continue ...

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Abstract

The invention discloses a preparation method capable of increasing the yield of creatine nitrate, which comprises: mixing water, activated carbon and phosphatidylcholine, adding creatine monohydrate and stirring at room temperature for 10-20min, and the stirring speed is 1200-1600r / min , reduce the speed to 100‑400r / min, and continue to stir for 2‑4h to obtain pretreated creatine; stir the pretreated creatine at room temperature, slowly add nitric acid solution during the stirring process, continue ultrasonic treatment for 1‑2h after the addition is complete, and ultrasonically The power is 300-400W, the ultrasonic frequency is 15-20kHz, and the preform is obtained; the preform is filtered to remove the solid matter, and the temperature of the remaining liquid is slowly cooled, firstly, the temperature is lowered from room temperature to 10-15°C at a rate of 1-2°C / min. ℃, stand still for 1-2h, continue to cool down to 1-5°C at a rate of 0.1-0.2°C / min, let stand for 2-4h, vacuum-dry, and cool to obtain creatine nitrate.

Description

technical field [0001] The invention relates to the technical field of creatine preparation, in particular to a preparation method that can improve the yield of creatine nitrate. Background technique [0002] Creatine is an important muscle-replenishing nutrient used by the body to improve and enhance muscle performance and strength. At the same time, creatine also has the effect of treating heart disease, enhancing cognitive function and treating asthma. The market demand for it is increasing. However, creatine is a substance that is not easily soluble in water, and this characteristic seriously affects oral administration and absorption. For this reason, a variety of inorganic acid salts, organic acid salts and esters of creatine have been prepared. Studies have found that the nitrate of creatine has better water solubility, and it can also improve vasodilation and blood circulation after oral administration. [0003] At present, the preparation method of relevant creat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C277/08C07C279/14
CPCC07C277/08C07C279/14
Inventor 苏迎春
Owner 湖南天成生化科技有限公司
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