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Fast release benzoic acid in feed

A technology of benzoic acid and feed, applied in animal feed, animal feed molding or processing, application, etc., can solve the problem that needle-like crystals are not suitable for animals

Pending Publication Date: 2021-02-09
DSM IP ASSETS BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Needle crystals are not suitable for feeding animals

Method used

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  • Fast release benzoic acid in feed
  • Fast release benzoic acid in feed
  • Fast release benzoic acid in feed

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] The preparation of simulated gastric juice is described, for example, in the USP: 2.0 g of sodium chloride and 3.2 g of purified pepsin (derived from porcine gastric mucosa) at an activity of 800 to 2500 units per mg of protein were dissolved in 7.0 mL of hydrochloric acid and Enough water to make 1000mL. The pH of the test solution is about 1.2.

[0040] Parameters relevant to this dissolution test include temperature, stirring speed and flow rate. When comparing the dissolution rates of two or more samples, these parameters must remain at predetermined values. In one embodiment, at least 60%, preferably at least 65%, of the pellet of benzoic acid has dissolved in simulated gastric fluid after 30 minutes when dissolution is measured in a USP-4 release tester using the following parameters:

[0041] Test temperature: 37.0°C

[0042] Pumping volume: 8ml / min.

[0043] Pool: 12mm

[0044] Buffer: HCl pH 2

[0045] One embodiment of the present invention relates to be...

Embodiment approach

[0055] CLAIMS 1. A method of controlling the release of benzoic acid in the intestine of an animal, wherein the surface area / volume ratio of crystalline benzoic acid is reduced by providing pellets of benzoic acid.

[0056] 2. Composition comprising benzoic acid pellets for balancing the flora in the gastrointestinal system of an animal and / or for reducing digestive disturbances in the animal.

[0057] 3. The composition according to embodiment 2 for balancing the flora in the gastrointestinal system of chickens or pigs and / or for reducing digestive disturbances in chickens or pigs.

[0058] 4. Animal food containing benzoic acid pellets.

[0059] 5. The animal food according to embodiment 4, wherein the animal food is a feed additive, premix or feed.

[0060] 6. Animal food according to embodiment 4 or 5, which additionally comprises at least one flavoring substance, grain, flour mill by-products, at least one vitamin, at least one inorganic salt and / or protein.

[0061] 7....

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Abstract

The present invention relates to the use of benzoic acid prills in the feed industry. Despite of having a reduced surface area / volume ratio, the benzoic acid prills as used in the context of the present invention release benzoic acid faster than benzoic acid flakes. Compositions comprising such prills are useful for balancing the microflora in an animal's gastro-intestinal system, for acidification of feed and / or urine, and / or for reducing digestive disorders of an animal.

Description

technical field [0001] The present invention relates to the purposes of benzoic acid in feed industry. Background technique [0002] Benzoic acid is currently being used in the feed industry. It is a colorless solid that melts at about 122°C. [0003] Crystalline benzoic acid is commercially available as white flakes / flakes or as needle-like crystals. Commercially available feed premixes contain benzoic acid flakes. Needle crystals are not suitable for feeding animals. [0004] WO 2012 / 049013 A1 discloses the use of benzoic acid in a feed concentrate for preventing and / or treating urolithiasis, reducing the number and / or size of urinary uroliths and / or improving the welfare of ruminants. [0005] WO 98 / 08499 A1 relates to compositions comprising benzoic acid for use as animal medicine, wherein the acid acts as an antibiotic, promotes growth, reduces feed conversion and improves digestibility of amino acids administered in animal feed. Benzoic acid can be administered to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/111A23P10/22A23P30/00
CPCA23K20/111A23P10/22A23P30/00A23K20/158A23K40/10A23K50/30A61K9/0056A61K9/1617A61K9/1688A61K31/192
Inventor 劳雷·克拉萨达蒂艾勒格·范纳尼古拉斯·哈格曼卡斯滕·彼得森-帕萨雷纳·斯特布纳
Owner DSM IP ASSETS BV
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