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Composition for supporting animal with cancer

A composition, dry matter technology, used in pharmaceutical combinations, animal feed, animal feed, etc.

Pending Publication Date: 2021-02-12
MARS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] There is currently no commercially available diet that is specially formulated and clinically validated to support optimal nutritional status and quality of life in pets with cancer and to help reduce the gastrointestinal side effects of chemotherapy

Method used

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  • Composition for supporting animal with cancer
  • Composition for supporting animal with cancer
  • Composition for supporting animal with cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0236] Example 1: Effect of Novel Diet on Quality of Life in Dogs Undergoing Chemotherapy

[0237] Purpose :

[0238] Cancer is one of the most common causes of death in dogs, and pet owners are increasingly choosing to treat their pets with chemotherapy to prolong their good quality of life (QOL) for as long as possible. The purpose of this double-blind, multicenter, randomized clinical trial was to investigate a novel high-protein, low-carbohydrate, moderate-fat (relative to typical dry food), containing increased fiber content and supplemented with omega-3 fatty acids (omega-3 fatty acids). 3fat acid), quality of life (QOL) and gastrointestinal health in dogs undergoing chemotherapy for mast cell tumor (MCT) and multicentric lymphoma (LSA) during an 8-week feeding period Effect.

[0239] A.Materials and methods

[0240] Forty-five chemotherapy-naïve client-owned dogs newly diagnosed with multicentric LSA or high-grade, metastatic, or unresectable MCT were treated with ...

Embodiment 2

[0292] Example 2: Anti-proliferative activity of various plant extracts

[0293] A.Materials and methods

[0294] A.1. Natural extracts were received directly from the manufacturer and the content of each compound of interest based on the manufacturer's purity analysis was verified by a secondary laboratory. Before each experiment, the extract was dissolved in 100% DMSO at 20 mg / mL to obtain a stock solution.

[0295] Table 8: Characteristics of natural extracts

[0296]

[0297] a Purity values ​​represent the percentage of the main compound of interest in each extract as determined by the manufacturer (for a specific batch)

[0298] A.2. The chemotherapeutic agent used was toceranib phosphate (Palladia) TM , Zoetis Animal Health) and doxorubicin hydrochloride (Sigma Aldrich). Doxorubicin (positive reference) was prepared at 200Mm (stock solution for proliferation assay)

[0299] A.3. Multiple canine tumor primary cell lines were used to represent different tumor ...

Embodiment 3

[0415] Example 3: In vivo example with final combination

[0416] The purpose of this prospective multicenter clinical trial was to determine whether a specially formulated experimental diet could enhance the efficacy of chemotherapy, reduce its side effects and maintain quality of life (QoL) in dogs undergoing chemotherapy regimens. The clinical efficacy of this new diet will be assessed within 1 year of the cancer diagnosis. The main goal is to help dogs fight cancer through "supportive care" to maintain good nutritional status. The study was designed as a double-blind randomized placebo-controlled trial. Primary outcomes were global health status / QoL score, gastrointestinal (GI) adverse events, and weight maintenance. Secondary efficacy parameters were other QoL scores (functional and symptom scales), stool scores (parameters related to GI-AEs), median survival, 1-year survival rate, treatment response rate, hematologic adverse events (H-AEs ), diet assessed by the own...

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Abstract

The present disclosure relates to a dog food composition comprising from about 10% by weight to about 20% by weight of fat, from about 5% by weight to about 15% by weight of fibers and from about 30%by weight to about 60% by weight proteins, the weight percentages being based on the total weight of dry matter of the composition.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority from European Patent Application No. EP18177847.3 filed on June 14, 2018, the entire contents of which are hereby incorporated by reference. technical field [0003] The present disclosure is in the field of food compositions for dogs with cancer. Background technique [0004] The maintenance and improvement of animal health is an ongoing goal in the art. Like their human counterparts, the life expectancy of pets living in developed countries has been increasing. As a result, the global cancer burden continues to increase, largely due to aging and growing dog populations. For example, the estimated incidence of cancer in the dog population ranges from 282.2 to 958 cases per 100,000 dogs. The most common tumors in dogs were mammary tumors in female dogs (70.5% of all cancers), non-Hodgkin's lymphoma (8.4% in females and 20.1% in males), and skin tumors (4% in females a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/40A23K50/42A61P35/00A61P39/06
CPCA23K50/42A23K50/40A61P35/00A61P39/06A61K31/375A61K31/355A61K36/9066A61K36/53A23K20/147A23K10/30A23K20/158A23K20/174A23K20/179Y10S426/805A23K50/48
Inventor J·培尔D·莫尼奥V·比乌尔治Y·凯奥G·达尼埃尔
Owner MARS INC
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