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Codonopsis glucan with immunoregulatory effect, its preparation method and application

A technology of immune regulation and dextran, which is applied in the fields of application, function of food ingredients, allergic diseases, etc., and can solve the problem that there is no relevant report on the immune regulation of Codonopsis dextran

Active Publication Date: 2022-04-19
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are almost no related reports on the immune regulation of Codonopsis glucan

Method used

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  • Codonopsis glucan with immunoregulatory effect, its preparation method and application
  • Codonopsis glucan with immunoregulatory effect, its preparation method and application
  • Codonopsis glucan with immunoregulatory effect, its preparation method and application

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Embodiment Construction

[0064] Specific embodiments of the present invention will be described in detail below.

[0065] 1. The preparation of Codonopsis glucan with immunomodulatory effect is as follows:

[0066] (1) Codonopsis polysaccharide extraction

[0067] Codonopsis pilosula is soaked for 30 minutes according to the material-to-liquid ratio of 1:10~1:20, heated and refluxed for 3 times, each time for 1.5 hours, and the three extracts are combined.

[0068] (2), preparation of Codonopsis polysaccharide

[0069] Codonopsis polysaccharide extract was concentrated under reduced pressure to 1 / 4~1 / 3 volume, precipitated with 60%~80% ethanol, centrifuged at 1000 rpm for 15min, removed the supernatant, and precipitated with ether, ethyl acetate, acetone, anhydrous Washed with ethanol three times in sequence, and freeze-dried to obtain a polysaccharide sample of Codonopsis pilosula.

[0070] (3) Ultrafiltration separation of Codonopsis polysaccharide

[0071] Dissolve Codonopsis polysaccharide in ...

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Abstract

The invention discloses Codonopsis glucan with immune regulation function, its preparation method and application. The main chain of Codonopsis glucan is connected by α-D-glucopyranose 1→4 glycosidic bonds, and the branch chain is β-glucopyranose D-glucopyranose is formed by linking 6→1, and is formed by linking structural unit A and structural unit B at a ratio of 15-17:1. The molecular weight of Codonopsis glucan is 1500-2000 Da. The preparation method of Codonopsis glucan comprises the following steps: (1) Extraction of Codonopsis total polysaccharide; (2) Ethanol precipitation of Codonopsis total polysaccharide extract; (3) Ultrafiltration separation of Codonopsis polysaccharide. The application of the codonopsis glucan in the fields of medicine, health products, health food and food.

Description

technical field [0001] The invention relates to the technical field of preparation of active ingredients of traditional Chinese medicines, in particular to Codonopsis glucan with immune regulation function, its preparation method and application. Background technique [0002] Radix Codonopsis (Radix Codonopsis) is the dried root of Radix Codonopsis, Radix Codonopsis and Sichuan Codonopsis. Codonopsis Codonopsis has the effects of invigorating the middle and replenishing Qi, invigorating the spleen and benefiting the lungs, and is clinically used for symptoms such as spleen and lung weakness, shortness of breath, palpitations, lack of appetite, loose stools, asthma and cough due to deficiency. Codonopsis pilosula mainly contains polysaccharides, triterpenes, alkynoids, alkaloids, phenylpropanoids and other components, among which polysaccharides have the highest content and are important pharmacologically active components of Codonopsis pilosula. However, there are almost no...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/02A23L33/125A61P37/02
CPCC08B37/0009C08B37/0003A23L33/125A61P37/02A23V2002/00A23V2250/5042A23V2250/21A23V2200/324
Inventor 李建宽高建平王妍
Owner SHANXI MEDICAL UNIV