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A simultaneous detection method of sweat multi-component content and pH based on mobile terminal photography colorimetry

A technology of mobile terminal and detection method, which is applied in the direction of material analysis, measuring device, and analysis material through observation of the influence of chemical indicators, and can solve problems such as high hardware cost, damage to fit tightness, pollution and wearing comfort , to achieve the effects of eliminating uncertainty, high measurement accuracy, and convenient and quick detection process

Active Publication Date: 2021-07-30
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of sensor system can continuously monitor the concentration of certain chemical substances in sweat, the hardware cost of the system is relatively high and due to the inflexible form factor of the equipped electronics and subsystems, it will damage the contact with the skin when the human body moves. Fit tightness (causes sweat to be "contaminated" by external fluids or impurities) and wearing comfort

Method used

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  • A simultaneous detection method of sweat multi-component content and pH based on mobile terminal photography colorimetry
  • A simultaneous detection method of sweat multi-component content and pH based on mobile terminal photography colorimetry
  • A simultaneous detection method of sweat multi-component content and pH based on mobile terminal photography colorimetry

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] In this embodiment, a method for simultaneous detection of multiple components of flexible wearable sweat based on mobile terminal photography colorimetry comprises the following steps:

[0048] (1) Take pictures in a fixed color temperature environment to establish the indicator concentration calculation curve

[0049] (1) On the flexible rubber SEBS base film, use a 200μm steel plate to hollow out and print a color temperature calibration ring with 6 colors. The 6 color temperature calibration colors are white (R255, G255, B255), gray 1 (R140, G140, B140) , gray 2 (R120, B120, G120), red (R220, G70, B60), yellow (R220, B210, B90), green (R65, G175, B165), such as figure 1 shown.

[0050] (2) will contain different pH values ​​(4.4, 5.0, 5.6, 6.2, 6.8, 7.4), different calcium ion concentration values ​​(0, 3, 5, 6, 8, 15mM), different chloride ion concentration values ​​(0, 25, 50, 75, 100, 125mM) Standard solution test paper with different glucose concentration valu...

Embodiment 2

[0086] The present invention utilizes the fitting curve that limited measuring point establishes to calculate the measured value of known and unknown point, measurement and calculation result: pH and Ca 2+ The uncertainties of concentration are 0.13 and 0.48mM respectively, which can fully meet the needs of quantitative measurement of sweat components.

[0087] Take pH as an example to illustrate the calculation process, as follows:

[0088] After obtaining the color CIE coordinates of the 6 pH elastic test papers at a fixed color temperature (such as 6500K), add the ordinate information (pH value), namely (x1 y1 4.4), (x2 y2 5.0), (x3 y3 5.6), (x4 y4 6.2), (x5 y5 6.8), (x6 y67.4), use the coordinates of these 6 points to establish a three-dimensional spline curve.

[0089]During calculation, compare the color CIE(x y) of the paper to be tested with the above-mentioned three-dimensional spline spline curve, find the nearest point on the curve, and then the ordinate of this po...

Embodiment 3

[0093] Determination of pH, Cl-concentration and Ca without color temperature calibration 2+ concentration:

[0094] (1) The pH value (4.4, 5.0, 5.6, 6.2, 6.8, 7.4), calcium ion concentration value (0, 3, 5, 6, 8, 15mM) and chloride ion concentration value (0 , 25, 50, 75, 100, 125mM) test papers are placed in the calibration ring at the same time.

[0095] (2) Under the ambient light with a color temperature of 6500K, use Iphone XR to take pictures of the above combination.

[0096] (3) Use Adobe Photoshop to extract the average R channel intensity, the average G channel intensity and the average B channel intensity of the pH, calcium ion concentration, and chloride ion concentration test paper in the above photos, as shown in Figures 2-4.

[0097] (4) Convert the RGB values ​​of the pH, calcium ion concentration and chloride ion concentration test paper in the picture into the CIE color coordinate value x / y, the specific method is:

[0098] / / sR, sG and sB (Standard RGB) ...

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Abstract

The invention discloses a method for simultaneously detecting multi-component content and pH of sweat based on a colorimetric method photographed by a mobile terminal. A three-dimensional standard curve for detecting sweat components or pH is constructed by using a spline fitting method at a calibrated color temperature. Establish the respective linear calibration lines of the RGB color channels of the calibration color circle, and then bring the regional average value of the intensity of each RGB channel of the test paper with unknown sweat composition or pH into the above-mentioned RGB linear calibration line to convert the calibrated color temperature Download the intensity value of the corresponding RGB channel and convert it into the corresponding CIE1931 color coordinate value, and use the three-dimensional standard detection curve to calculate the multi-component content or pH of sweat. The invention uses a set of color temperature calibration colors to eliminate the uncertainty of colorimetric detection of wearable colorimetric sensors, realize simultaneous measurement of sweat multi-component content and pH, and obtain high measurement accuracy, which fully meets the requirements for wearable sweat components. Portable testing needs.

Description

technical field [0001] The invention belongs to the field of image processing and detection, and in particular relates to a method for simultaneously detecting multi-component content and pH of sweat based on mobile terminal photography colorimetry. Background technique [0002] Body fluid testing is the most widely used diagnostic method in medical institutions. Among them, blood analysis is considered to be the gold standard in the field of biometric analysis, and it is an essential detection process for routine physical examination and screening of a large number of diseases. The blood collection process for blood analysis is traumatic to the human body, often causing resistance, and there is also an obvious risk of wound infection. Sweat offers a non-invasive, non-invasive alternative. Sweat is a body fluid secreted by sweat glands, which contains rich electrolytes (such as chloride ions, calcium ions), metabolites (such as glucose, lactic acid) and acid-base (pH) info...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/78G01N21/80
CPCG01N21/78G01N21/80G01N2021/7759
Inventor 张奎奎孔德圣
Owner NANJING UNIV