Method for filtering hyaluronic acid by adopting candle filter
A technology of hyaluronic acid and hyaluronic acid, which is applied in the field of biomedicine, can solve problems such as low filtration efficiency, incomplete slag removal, and filter cake adhesion, and achieve the effects of improving cleaning, shortening production cycle, and loose structure
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Embodiment 1
[0037] A. Add 0.1% diatomaceous earth and 1% perlite to the hyaluronic acid solution with a concentration of 10wt%, and then use a candle filter to filter the liquid at a speed of 0.4m 3 / (m 2 • h), with the increase of time, the filter cake layer gradually forms and becomes thicker, the speed of the filtrate passing through the filter cake decreases, and the filtration efficiency becomes worse. When the filter pressure increases and the filtering effect does not meet the requirements, stop filtering and carry out Remove slag. Slag removal is carried out as follows:
[0038] (1) Introduce NaOH solution with a temperature of 50°C and a concentration of 0.3% (w / v) from the liquid inlet of the candle filter to rinse the candle filter at a speed of 0.6m 3 / (m 2 • h), for 7 minutes;
[0039] (2) After rinsing is completed, hot air with a temperature of 65°C is introduced for 7 minutes;
[0040] (3) Blow in normal temperature air in the reverse direction, blow off the filter resi...
Embodiment 2-5 and comparative example 1-9
[0045] The hyaluronic acid solution was filtered according to the method of Example 1, the difference was that when removing slag, the conditions for washing in step (1) were different from the conditions for introducing hot air in step (2). The details are shown in Table 1 below:
[0046]
[0047] By filtering 30 tons of hyaluronic acid solution process, calculate the mean value of the slag removal rate each time, as the average slag removal rate of each slag removal process, the average slag removal rate of each embodiment and comparative example and filter 30 tons of hyaluronic acid The total time T used for the solution is shown in Table 2 below:
[0048]
[0049] As can be seen from the results in Table 2, the present invention realizes automatic 100% shedding of filter residue and continuous operation of candle filter by regulating the temperature, concentration, time of flushing liquid NaOH solution and the temperature and time of feeding hot air. The overall fil...
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