Silicone hydrogel contact lenses having non-uniform morphology

A contact lens and silicone technology, applied in home appliances, other home appliances, glasses/goggles, etc., can solve problems such as excessive eye deposits and reduced visual acuity, reduce costs, and simplify the manufacturing process Effect

Pending Publication Date: 2021-03-02
强生视力健公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some wearers still experience discomfort and excess ocular deposits resulting in reduced visual acuity when using these lenses, especially during extended periods of wear such as consecutive days (e.g. up to about 30 days)

Method used

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  • Silicone hydrogel contact lenses having non-uniform morphology
  • Silicone hydrogel contact lenses having non-uniform morphology
  • Silicone hydrogel contact lenses having non-uniform morphology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 9

[0384] A reactive monomer mixture was prepared consisting of 77% by weight of the formulation listed in Table 1 and 23% by weight of diluent D3O. Filter the reactive monomer mixture separately through a 3 μm filter using a stainless steel syringe. Then, at the time of use, about 0.074 grams of AIBN (thermal initiator) was dissolved in 20.0000 grams of RMM. The weight percent of AIBN in the final RMM was about 0.37% by weight.

[0385] The RMM with AIBN was degassed at ambient temperature by applying vacuum (40 Torr) for at least 20 minutes. Then, about 75 μL to 80 μL of the reactive mixture was dosed with an Eppendorf pipette into the FC made of Zeonor at room temperature in a glove box with a nitrogen atmosphere and less than about 0.2% oxygen. A BC made of a 55:45 (w / w) Z:PP blend was then placed onto the FC. The molds were allowed to equilibrate in the glove box for a minimum of twelve hours prior to batching. Approximately 20 pallets each comprising eight mold assembli...

Embodiment 8 to 11

[0410] A reactive monomer mixture was prepared consisting of 77% by weight of the formulation listed in Table 5 and 23% by weight of diluent D3O. PVMA from Preparation 1 was used. Filter the reactive monomer mixture separately through a 3 μm filter using a stainless steel syringe. Then, at the time of use, about 0.037 grams of AIBN (thermal initiator) was dissolved in 10.0000 grams of RMM. The weight percent of AIBN in the final RMM was about 0.37% by weight.

[0411] The RMM with AIBN was degassed at ambient temperature by applying vacuum (40 Torr) for at least 20 minutes. Then, about 70 μL to 75 μL of the reactive mixture was dosed with an Eppendorf pipette into the FC made of Zeonor at room temperature in a glove box with a nitrogen atmosphere and less than about 0.2% oxygen. A BC made of a 55:45 (w / w) Z:PP blend was then placed onto the FC. The molds were allowed to equilibrate in the glove box for a minimum of twelve hours prior to batching. Approximately 20 pallets ...

Embodiment 12 to 14

[0431] A reactive monomer mixture was prepared consisting of 77% by weight of the formulation listed in Table 9 and 23% by weight of diluent D3O. Filter the reactive monomer mixture separately through a 3 μm filter using a stainless steel syringe. Then, at the time of use, about 0.0285 grams of AIBN (Thermal Initiator) was dissolved in 10.0000 grams of RMM. The weight percent of AIBN in the final RMM was about 0.28% by weight.

[0432] The RMM with AIBN was degassed at ambient temperature by applying vacuum (40 Torr) for at least 20 minutes. Then, about 75 μL of the reactive mixture was dosed with an Eppendorf pipette into the FC made of Zeonor at room temperature in a glove box with a nitrogen atmosphere and less than about 0.1% to 0.2% oxygen. Then, place the BC, also made of Zeonor, onto the FC. The molds were allowed to equilibrate in the glove box for a minimum of twelve hours prior to batching.

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Abstract

Described is a silicone hydrogel contact lens having non-uniform morphology. The contact lens may be made from a reactive mixture comprising: a silicone-containing component; a hydrophilic component;a non-reactive polymeric internal wetting agent; and a polymerization initiator, the contact lens having an oxygen permeability of at least about 60 barrers, and wherein the molar ratio in the lens ofthe polymeric non-reactive internal wetting agent to silicone, without a surface treatment, is greater in the lens's surface than in its bulk.

Description

[0001] related application [0002] This application claims priority to U.S. Patent Application Serial No. 16 / 875,164, filed May 15, 2020, and U.S. Provisional Patent Application Serial No. 62 / 865,586, filed June 24, 2019, which are incorporated by reference in their entirety This article. technical field [0003] The present invention relates to silicone hydrogel contact lenses with heterogeneous morphology. More specifically, the present invention relates to silicone hydrogel contact lenses comprising a non-reactive polymeric internal wetting agent that is more concentrated in the surface of the lens than in its bulk. Background technique [0004] Soft contact lenses are based on hydrogels. Many users find that soft contact lenses are comfortable enough to wear all day. There are two main classes of soft contact lens materials: conventional soft contact lenses formed from silicone-free hydrogels, and soft contact lenses formed from silicone hydrogels. [0005] Silicon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B1/04
CPCG02B1/043C08F230/08C08J3/075C08J2383/04C08J2443/04C08J2439/06C08G77/20C08F220/54C08F230/085C08F220/20C08F220/36C08F222/102C08F220/387C08L39/06C08L43/04C08L101/14G02C7/049B29D11/00038C08L83/04C08J2439/00C08L2203/02
Inventor A·艾莉D·E·里德勒A·古兹曼B·桑塔玛利亚
Owner 强生视力健公司
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