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Novel application of heparin or derivative thereof or pharmaceutically acceptable salt thereof

A technology of derivatives and medicinal salts, which is applied in the field of preparation of drugs for the prevention or treatment of mental illness, can solve the problems of undiscovered application of heparin in bipolar disorder, and achieve significant curative effect, less toxic and side effects, and prevent relapse

Pending Publication Date: 2021-03-05
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of heparin in bipolar disorder has not been found so far

Method used

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  • Novel application of heparin or derivative thereof or pharmaceutically acceptable salt thereof
  • Novel application of heparin or derivative thereof or pharmaceutically acceptable salt thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 heparin tablet

[0026] Take heparin, mix with microcrystalline cellulose and sodium carboxymethyl starch, add appropriate amount of starch slurry to make soft material, granulate, dry, granulate, add magnesium stearate, mix evenly, and compress into tablets.

Embodiment 2

[0027] The preparation of embodiment 2 heparin granules

[0028] Take heparin, add microcrystalline cellulose and sucrose, mix evenly, granulate, dry, granulate, pack, and obtain.

Embodiment 3

[0029] The preparation of embodiment 3 heparin capsules

[0030] Heparin and croscarmellose sodium are fully mixed, granulated, dried to obtain granules, granulated, added with magnesium stearate, mixed evenly, filled with capsules, packaged, and obtained.

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PUM

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Abstract

The invention belongs to the field of medicines, and particularly relates to application of heparin or a derivative thereof or a pharmaceutically acceptable salt thereof in preparation of a medicine for preventing or treating mental diseases. The mental diseases are preferably one or a combination of more than two of depression, mania, learning and memory ability disorder and insomnia, and are further preferably bipolar disorder. The heparin or the derivative thereof or the pharmaceutically acceptable salt thereof is prepared into a composition by a conventional preparation method, and / or is added with an emotion stabilizer to prepare a medicine composition; and the prepared product solves the technical problems that the bipolar disorder is complicated in condition, difficult to treat andeasy to repeatedly attack. The heparin has a significant two-way regulation effect on depressive attack and mania attack of the bipolar disorder, has the advantages of being small in toxic and side effects and capable of preventing repeated attack, and has a good prospect of being developed into a medicine for preventing and treating the bipolar disorder.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the new medical application of heparin, or its derivative, or its pharmaceutically acceptable salt, especially the application in the preparation of drugs for preventing or treating mental diseases. Background technique [0002] Bipolar affective disorder is one of the common clinical mental disorders. It has the characteristics of complex condition, long course of disease, difficult treatment, easy recurrent attacks, and high disability rate. It is usually accompanied by alternating symptoms of depressive episodes and manic episodes. In particular, learning and memory impairment and insomnia seriously affect the normal life of the patient, and then constitute a great adverse effect on the patient's physical and mental health. With the continuous increase of people's life and work pressure in recent years, the rate of depressive episodes of bipolar disorder shows a trend of increasing year ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/727A61P25/24A61P25/18A61P25/20A61P25/00
CPCA61K31/727A61P25/24A61P25/18A61P25/20A61P25/00
Inventor 张贵民徐燕彭涛
Owner LUNAN PHARMA GROUP CORPORATION