Bacterial outer membrane vesicle, universal nano vaccine containing bacterial outer membrane vesicle as well as preparation method and application thereof

A technology of outer membrane vesicles and nano-vaccine, which is applied in the direction of medical preparations containing active ingredients, nanotechnology, nanotechnology, etc., can solve the problems that do not involve tumor antigens and specific immunity, and achieve good tumor suppression effect, biological Good compatibility, the effect of inhibiting lung metastasis
CN112472802AActive Publication Date: 2021-03-12THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Publication Date
2021-03-12

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Abstract

The invention relates to a bacterial outer membrane vesicle, a nano vaccine containing the bacterial outer membrane vesicle as well as a preparation method and application thereof. The bacterial outermembrane vesicle contains molecular gluewater protein SpyCatcher and / or SnoopCatcher, the tumor vaccine comprises the bacterial outer membrane vesicle and an antigen connected with the bacterial outer membrane vesicle in the form of an isopeptide bond, and the antigen carries SpyTag and / or SnoopTag. According to the invention, the bacterial outer membrane vesicle containing molecular gluewater protein SpyCatcher and SnoopCatcher is used as a tumor vaccine platform and is connected with the antigen carrying SpyTag and / or SnoopTag to obtain the tumor vaccine, and the tumor vaccine can effectively activate an organism to generate innate immunity and realize specific killing of a plurality of antigens at the same time. According to the method, personalized tumor vaccines for tumors from different sources can be rapidly obtained.
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Description

technical field

[0001] The invention relates to the technical field of nano-medicines, in particular to a bacterial outer membrane vesicle, a universal nano-vaccine containing the bacterial outer membrane vesicle, a preparation method and application thereof. Background technique

[0002] In recent years, with the development of molecular biology and tumor immunology, tumor immunotherapy has become the most potential tumor treatment after surgery, chemotherapy, radiotherapy and molecular targeted therapy. Tumor immunotherapy is a treatment method that controls and eliminates tumors by restarting and maintaining the immune system's recognition and monitoring of tumors, and restores the body's normal anti-tumor immune response. It mainly includes immune checkpoint inhibitors, tumor vaccines, and cell therapy. and cytokine therapy. In recent years, tumor immunotherapy has developed rapidly, and it has demonstrated strong anti-tumor activity in the treatment of various tumors s...

Claims

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