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Application of crebanine in preparation of medicine for preventing or treating neurodegenerative diseases

A neurodegenerative and disease-related technology, applied in the field of medicine, can solve problems such as the prevention or treatment of neurodegenerative diseases that have not yet been seen, and achieve good and significant therapeutic effects

Active Publication Date: 2021-03-16
NORTHEASTERN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there have been no reports on the preventive or therapeutic effects of cbanning on neurodegenerative diseases

Method used

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  • Application of crebanine in preparation of medicine for preventing or treating neurodegenerative diseases
  • Application of crebanine in preparation of medicine for preventing or treating neurodegenerative diseases
  • Application of crebanine in preparation of medicine for preventing or treating neurodegenerative diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Effect of Kebanin on ischemic stroke in rats caused by middle artery ischemia-reperfusion

[0028] 1. Purpose of the experiment

[0029] Establish a model of ischemic stroke caused by ischemia-reperfusion of the middle artery, and evaluate the Keban Therapeutic effect of Ning on ischemic stroke.

[0030] 2. Experimental materials

[0031] 2.1. Experimental animals: healthy 6-8 week-old SPF grade male Sprague-Dawley (SD) rats, weighing 280-300g, purchased from the Experimental Animal Center of Shenyang Pharmaceutical University.

[0032] 2.2. Test drugs:

[0033] Cobanine spray preparation: self-made, based on the content of grambanine, the doses are 250 μg / kg and 500 μg / kg respectively. Blank spray preparation: self-made, prepared in parallel with the above-mentioned Kebanin spray preparation, the main components are dilute ethanol and medical high-purity water. Butylphthalide: NBP Pharmaceutical Co., Ltd. of CSPC, approved by H20050299.

[0034] 3. Exp...

Embodiment 2

[0063] Example 2: Therapeutic effect of Kebanin on AD model mice injected with lipopolysaccharide bilaterally

[0064] 1. Purpose of the experiment

[0065] Alzheimer's disease is one of the common neurodegenerative diseases in middle-aged and elderly people. In this experiment, the mouse model of dementia induced by lipopolysaccharide (LPS) was injected into the bilateral hippocampal ventricle, and the therapeutic effect of Kebanin on AD mice was evaluated by observing the learning and memory ability of the mice and the changes in the number of neurons.

[0066] 2. Experimental materials

[0067] 2.1. Experimental animals: healthy 6-8 week-old SPF male C57BL / 6 mice, weighing 20-25 g. purchased from the Animal Experiment Center of Shenyang Pharmaceutical University.

[0068] 2.2. Drug under test: Carbanine suspension: self-made, based on carbanine content, dissolved in CMC-Na solution, with three specifications of 5mg / mL, 10mg / mL and 20mg / mL respectively. Donepezil hydroch...

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Abstract

The invention relates to medical application of crebanine in preventing or treating neurodegenerative diseases, belongs to the field of medicines, and particularly relates to crebanine for improving cerebral arterial thrombosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis or Huntington's disease. Pharmacological experiments show that the crebanine has a good treatment effect on cerebral arterial thrombosis caused by middle cerebral artery ischemia reperfusion and has a remarkable treatment effect on Alzheimer's disease model mice caused by LPS, and therefore, the crebanine can be used for preparing the medicine for preventing or treating neurodegenerative diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the new medical application of carbanin in the preparation of medicines for preventing or treating neurodegenerative diseases. Background technique [0002] Neurodegenerative diseases are a group of progressive, disabling, and even fatal complex diseases characterized by the loss of a large number of specific neurons. It can be divided into acute neurodegenerative diseases and chronic neurodegenerative diseases. The former mainly includes stroke and brain injury; the latter mainly includes Alzheimer's disease (AD), Parkinson's disease (Parkinson's disease, PD), Amyotrophic lateral sclerosis (Amyotrophic lateral sclerosis, ALS), Huntington's disease (Huntington's disease, HD), etc. Although the lesion sites and causes of these diseases are different, the irreversible degeneration of neuron cells is one of the common features of these diseases. Patients with this type of disea...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61K45/06A61K31/365A61K31/445A61P9/10A61P25/28A61P25/16A61P25/14
CPCA61K31/4741A61K45/06A61K31/365A61K31/445A61P9/10A61P25/28A61P25/16A61P25/14A61K2300/00
Inventor 侯悦李宁何大阔杨艳秋
Owner NORTHEASTERN UNIV
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