Unlock instant, AI-driven research and patent intelligence for your innovation.

Pyrrolo[1,2-b] pyridazine derivatives

A kind of compound, the technology of composition, be used in the inhibitor of kinase IRAK4, prepare the compound field

Pending Publication Date: 2021-03-16
GILEAD SCI INC
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are currently no approved IRAK4 inhibitors

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pyrrolo[1,2-b] pyridazine derivatives
  • Pyrrolo[1,2-b] pyridazine derivatives
  • Pyrrolo[1,2-b] pyridazine derivatives

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0085] Prepare hard gelatin capsules containing:

[0086] quantity

[0087]

[0088] The above ingredients are mixed and filled into hard gelatin capsules.

preparation Embodiment 2

[0090] The tablet formulation is prepared using the following ingredients:

[0091] quantity

[0092]

[0093] These ingredients are mixed and compressed into tablets.

preparation Embodiment 3

[0095] A dry powder inhaler formulation is prepared comprising:

[0096] Composition Weight %

[0097] active ingredient 5

[0098] Lactose 95

[0099] The active ingredient is mixed with lactose and the mixture is added to a dry powder inhaler.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A compound of Formula (I): (I) pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.

Description

technical field [0001] The present disclosure relates to novel compounds that are inhibitors of the kinase IRAK4. The present disclosure also relates to methods of preparing the compounds and pharmaceutical compositions comprising the compounds. Background technique [0002] Interleukin-1 receptor-associated kinase 4 (IRAK4) is a serine-threonine kinase that acts as a mediator in the interleukin-1 / Toll-like receptor (IL-1 / TLR) signaling cascade. More specifically, IRAK4 is involved in the activation of the adapter protein myeloid differentiation primary response gene 88 (MyD88) signaling cascade and is thought to play a role in inflammatory and fibrotic disorders such as rheumatoid arthritis (RA), inflammatory Intestinal disease (IBD), gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), Sjogren's syndrome, viral myocarditis, acute and chronic tissue damage, Nonalcoholic steatohepatitis (NASH), alcoholic hepatitis, and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/04A61P17/06A61K31/5025
CPCC07D487/04A61P17/06A61P19/02Y02A50/30C07F5/025A61K31/435A61K31/5025A61P29/00
Inventor S.阿曼E.M.培根G.布里兹吉斯E.陈C.周J.J.科蒂尔M.恩杜克维J.G.泰勒N.E.赖特Z-Y.杨S.M.齐普费尔
Owner GILEAD SCI INC