Method for extracting chlorogenic acid n-butyl ester from peach blossoms

A technology of chlorogenic acid and n-butyl ester, which is applied in the preparation of carboxylate, chemical instruments and methods, preparation of organic compounds, etc., to achieve the effects of high extraction amount, simple extraction process and recyclable solvent

Active Publication Date: 2021-03-23
HUANGHE S & T COLLEGE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can be seen that n-butyl chlorogenic acid has broad application prospects, but there is no report on extracting n-butyl chlorogenic acid from plants of the genus Peach

Method used

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  • Method for extracting chlorogenic acid n-butyl ester from peach blossoms
  • Method for extracting chlorogenic acid n-butyl ester from peach blossoms
  • Method for extracting chlorogenic acid n-butyl ester from peach blossoms

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Embodiment 1

[0026] A method for extracting phenylpropanoids from peach blossoms, comprising the following steps:

[0027] 1) Take 2000 g of dried and pulverized peach blossoms as raw material, extract at room temperature with petroleum ether 12 times the weight of peach blossom raw materials (leaching 3 times, 3 days each time), filter after petroleum ether extraction, Recover the filter residue. Then use the 70% ethanol room temperature leaching of 13 times of raw material weight amount (leaching 3 times, each 3d), after ethanol leaching finishes, merge ethanol extract, filter, concentrate, obtain the total extract of 510 g ethanol;

[0028] Disperse the total ethanol extract in 50 mL water to form a dispersion, and then use petroleum ether (about 1 times the volume of the dispersion), ethyl acetate (about 1 times the volume of the dispersion) and n-butanol (about 1 times the volume of the dispersion) to form a dispersion. volume) extraction, each extracted 3 times, and the solvent was ...

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Abstract

The invention discloses a method for extracting a phenylpropanoid compound, namely chlorogenic acid n-butyl ester from peach blossoms. The method comprises the following steps: leaching the peach blossoms with petroleum ether, carrying out filtering, recovering filter residues, then performing leaching with ethanol at room temperature, and successively conducting filtering and concentrating to obtain an ethanol total extract; dispersing the ethanol total extract in a small amount of water to form a dispersion liquid, sequentially conducting extracting with solvents including petroleum ether, ethyl acetate and n-butyl alcohol, and recovering the solvents so as to obtain a petroleum ether part, an ethyl acetate part and an n-butyl alcohol part; mixing the n-butyl alcohol part with silica gel, carrying out silica gel column chromatography, and carrying out gradient elution with dichloromethane-methanol to obtain eight components; and mixing the component 5 with silica gel, carrying out packing, performing eluting with dichloromethane-ethyl acetate-methanol, carrying out thin-layer chromatographic detection, merging the same components, and recovering the solvents under reduced pressure to obtain the chlorogenic acid n-butyl este. The method provided by the invention is beneficial to better development and utilization of the medicinal plant, namely the peach blossoms, and is beneficial to sustainable utilization of the plant; an extraction process is simple; the solvents can be recycled; an extraction amount is high; and the method is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and in particular relates to a method for extracting phenylpropanoid compound n-butyl chlorogenic acid from peach blossoms. Background technique [0002] Peach blossoms belong to the Rosaceae (Rosaceae) peach genus ( Amygdalus ) plant peach ( Amygdalus persica L.) or mountain peach ( Amygdalus davidiana ) flower, bitter in taste, flat in nature, Guixin, liver, and large intestine meridian, beneficial to water and laxative, promoting blood circulation and removing blood stasis. [0003] Butyl chlorogenic acid is widely found in plants such as red notoginseng, sarsaparilla, and artemisia arborescens. Modern pharmacological studies have shown that it has a strong scavenging rate for DPPH free radicals. It can be seen that n-butyl chlorogenic acid has broad application prospects. However, there is no report on extracting n-butyl chlorogenic acid from plants of the genus Peach. The natu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/56C07C67/58C07C69/757A61P7/02
CPCC07C67/56C07C67/58A61P7/02C07C2601/14C07C69/757
Inventor 张伟张娟娟康文艺尹震花陈林
Owner HUANGHE S & T COLLEGE
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