Micro-fluidic chip and blood cell detection device
A technology of microfluidic chip and detection device, which is applied in measurement devices, enzymology/microbiology devices, fluid controllers, etc., can solve the problems of high equipment cost and high operation requirements, and achieve the reduction of equipment cost and the degree of instrument integration. The effect of high and low measurement cost
Active Publication Date: 2021-03-26
BOE TECH GRP CO LTD +1
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Problems solved by technology
[0007] The purpose of the present invention is to provide a microfluidic chip and a blood cell detection device, which can solve the problems of high cost of blood cell analysis equipment and high operation requirements in the prior art
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[0154] The pretreated sample to be tested enters the microfluidic chip from the sample inlet 100, first flows through the particle counting area, and enters each branch microchannel 310. Since the particle counting area is composed of a plurality of independent branch microchannels, each The width and depth of each branch microchannel are slightly larger than the size of a single white blood cell, so as to ensure the formation of single cell flow. When the sample to be tested flows between the microelectrodes in each branch microchannel 310, an impedance signal will be generated. The first detector distinguishes and counts different types of cells and counts white blood cells according to the impedance signals generated by cells of different sizes and structures;
[0155] Then, the samples to be tested converge again after passing through the particle counting area, and enter the confluent microchannel 320 of the immune detection area. Since the surface of the microelectrode ar...
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Abstract
The invention provides a micro-fluidic chip and a blood cell detection device. The micro-fluidic chip comprises: a sample inlet, a sample waste liquid collection port, and a sample micro-channel communicated between the sample inlet and the sample waste liquid collection port, wherein the sample micro-channel is internally provided with at least one pair of micro-electrodes, and the at least one pair of micro-electrodes can generate signal change to detect a to-be-detected sample when the to-be-detected sample passes through the sample micro-channel. The micro-fluidic chip and the blood cell detection device provided by the invention can solve the problems of high equipment cost and high operation requirements of a blood cell analysis instrument in the prior art.
Description
technical field [0001] The invention relates to the field of point-of-care diagnosis (POCT) in in vitro diagnosis (IVD), in particular to a microfluidic chip and a blood cell detection device. Background technique [0002] Microfluidic chip is a kind of science and technology characterized by manipulating fluid in micron-scale space. It has the ability to shrink the basic functions of biology, chemistry and other laboratories to a chip of a few square centimeters, so it is also called chip experiment. room. Microfluidic chips mostly form a network of microchannels, and controllable fluids run through the entire system to achieve various functions in conventional chemical or biological laboratories. The basic characteristics and greatest advantages of microfluidic chips are the flexible combination and large-scale integration of various unit technologies on a small and controllable platform. [0003] The biological particle counting function has a wide range of applications...
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IPC IPC(8): B01L3/00G01N33/50G01N33/537C12M1/34
CPCB01L3/5027B01L3/502761G01N33/5002G01N33/537B01L2200/061B01L2200/0636B01L2200/0652B01L2200/10B01L2300/0864B01L2400/0415B01L2300/0645
Inventor 崔皓辰张湛胡涛袁春根胡立教申晓贺
Owner BOE TECH GRP CO LTD