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Preparation of medicine for treating Alzheimer's disease

A technology for Alzheimer's disease and drugs, applied in the field of application of the combination of acyclovir and dexamethasone in the preparation of drugs for the treatment of Alzheimer's disease, which can solve problems such as unclear cognitive impairment

Pending Publication Date: 2021-03-30
PLANTARX LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether combination therapy with acyclovir and dexamethasone prevents cognitive impairment associated with Alzheimer's disease is largely unknown

Method used

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  • Preparation of medicine for treating Alzheimer's disease
  • Preparation of medicine for treating Alzheimer's disease
  • Preparation of medicine for treating Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Acyclovir and Dexamethasone Granules

[0097] Acyclovir 100g and dexamethasone 0.75g, lactose, starch, and low-substituted hydroxypropyl cellulose were respectively passed through a 60-mesh sieve, weighed according to the formula, placed in a mixer for 30 minutes, and added an appropriate amount of binder to prepare Soft material, 20-mesh granulation, drying, 18-mesh granulation, to obtain mixed powder, add prescription amount of magnesium stearate to the granulated granules and mix, and the mixed powder is divided into granules to make granules.

Embodiment 2

[0099] Acyclovir and Dexamethasone Capsules

[0100] Acyclovir 100g and dexamethasone 0.75g, lactose, starch, and low-substituted hydroxypropyl cellulose were respectively passed through a 60-mesh sieve, weighed according to the formula, placed in a mixer for 30 minutes, and added an appropriate amount of binder to prepare Soft material, 20 mesh granulation, drying, 18 mesh granulation, to obtain mixed powder, add prescription amount of magnesium stearate to the granules that have been granulated and mix, put the mixed powder in a capsule filling machine to fill capsules.

Embodiment 3

[0102] Acyclovir and Dexamethasone Tablets

[0103] Acyclovir 100g and dexamethasone 0.75g, lactose, starch, and low-substituted hydroxypropyl cellulose were respectively passed through a 60-mesh sieve, weighed according to the formula, placed in a mixer for 30 minutes, and added an appropriate amount of binder to prepare Soft material, 20-mesh granulation, drying, 18-mesh granulation, to obtain mixed powder, add the prescribed amount of magnesium stearate to the granulated granules and mix, after mixing evenly, take an appropriate amount of granules for content determination, according to the measured The content of the tablet is calculated by weight, compressed, and film-coated.

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Abstract

The invention relates to an application of combination of acyclovir and dexamethasone in preparation of a drug for treating Alzheimer's disease. According to the application, for all symptoms of Alzheimer's disease patients, especially cognitive impairment and neuroinflammation, it is found that the combined application of acyclovir and dexamethasone has a synergistic effect and exerts anti-inflammatory and immunomodulatory effects at the same time to achieve the treatment effect.

Description

technical field [0001] The invention relates to a new application of medicine, in particular to the application of combination of acyclovir and dexamethasone in the preparation of medicine for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is the most common chronic and irreversible neurodegenerative disease in the world. As the world's aging rate continues to increase, Alzheimer's disease is one of the greatest global medical challenges. However, effective treatments for this disease are still lacking. Cognitive impairment in Alzheimer's disease is associated with cholinergic degradation and excitotoxicity. Therefore, cholinesterase inhibitors, including donepezil, rivastamine, and galantamine, and the NMDA receptor antagonist memantine, are clinically used to treat Alzheimer's disease, but these drugs only relieve Symptoms of the disease, rather than preventing or delaying the progression of Alzheimer's disease. [0003] Acyclovir ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K31/522A61P25/28
CPCA61K31/573A61K31/522A61P25/28A61K2300/00A61P25/00Y02A50/30A61K9/4866A61K9/1652A61K9/2059A61K45/06
Inventor 蔡松烈
Owner PLANTARX LTD
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