Behavioural treatment
A behavioral, individual technique for problem behaviors in infants and preschoolers that addresses unstudied gut-brain associations and more
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Embodiment 1
[0162] Example 1 Association between infant gut microbiota during infancy and problem behavior at 2 years of age.
[0163] method
[0164]A. Sample and study design
[0165] The Barwon Infant Study (BIS) is a longitudinal Australian birth cohort study using an unselected prenatal sampling framework 16 (n=1074 infants) were pooled. Sociodemographic, family history, and maternal health data were collected from the first trimester, and stool samples were collected from 1-, 6-, and 12-month-old infants. The 16S rRNA gene was sequenced in a random subsample (n = 324), of which n = 201 had all relevant data available, and has been included in this study. Parents fill out the Child Behavior Scale when their child is 2 years old 17 (CBCL).
[0166] B. Microbiome
[0167] B.1 Collection and processing of stool samples
[0168] Fecal samples were collected from 1-, 6-, and 12-month-old BIS infants and stored at -80°C. In a random subsample of n=201 from BIS samples, 16S prepar...
Embodiment 2
[0220] Example 2 - Minimizing Anxiety Disorders in an Elevated Mouse Model
[0221] 1. Week 1 - Adaptation:
[0222] C57Bl / 6 wild-type mice were divided into 4 groups in the upper animal house, 4 mice per cage, and were not treated within a week, but closely monitored.
[0223] 2. Week 2 - Antibiotic therapy:
[0224] Administration of an antibiotic cocktail (1 g / L metronidazole, ampicillin, and neomycin) in drinking water for 7 days resulted in significant or complete elimination of bacteria (Bongers et al., 2014; Rakoff-Nahoum et al., 2004; Scher et al. , 2013).
[0225] 3. Week 3 - Bacterial inoculum preparation and P. Copri inoculation.
[0226] 4. Week 3-7 – P. Copri colonization
[0227] 5. Week 8 - Sucrose Preference Test
[0228]Animals had free access to 1% sucrose solution or normal water overnight. The bottles were weighed at the beginning and end of 17 hours. Since mice generally prefer sweet solutions over plain water, a diminished preference for sucrose ...
Embodiment 3
[0237] Example 3 Prevention of Internalizing Behavior at 2 Years Old
[0238] Take Prevotella or the gut bacterium Prevotella (P.copri) in infancy, preferably after the introduction of solid foods. When children were two years old, behavioral outcomes were assessed using the Children's Behavior Inventory. Once children reached school age, both parents and children assessed anxiety using the Spence Child Anxiety Inventory. Compare with placebo.
[0239] Without limitation, the invention can be summarized by the following
[0240] 1. A method of minimizing or reducing:
[0241] - the likelihood of problem behavior developing in the individual or
[0242] - the likelihood of individual problem behavior, or
[0243] - the development of problem behavior in the individual, or
[0244] - individual problem behavior,
[0245] The method includes administering to an individual a composition comprising a bacterium, wherein the composition comprises an effective amount of Prevo...
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