A kind of mesoporous bioactive glass/chitosan composite hemostatic sponge and preparation method thereof

A technology of bioactive glass and hemostatic sponge is applied in the field of medical devices to achieve the effects of stable quality, wide sources and good hemostatic properties

Active Publication Date: 2022-05-17
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to address the structural defects of existing sponges, to provide a bioactive glass / chitosan composite sponge with a hierarchical pore structure and a preparation method thereof, and to obtain a composite sponge with good hemostatic properties. sponge

Method used

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  • A kind of mesoporous bioactive glass/chitosan composite hemostatic sponge and preparation method thereof
  • A kind of mesoporous bioactive glass/chitosan composite hemostatic sponge and preparation method thereof
  • A kind of mesoporous bioactive glass/chitosan composite hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof, the preparation method of which is as follows:

[0047] (1) Preparation steps of mesoporous bioactive glass powder:

[0048] 1) Dissolve 0.6g of urea and 2g of cetylpyridinium bromide (CPB) in 150ml of deionized water, and stir evenly;

[0049] 2) After adding 42ml of cyclohexane, add 0.84g of isopropanol as a surfactant, and stir vigorously to form a uniform emulsion;

[0050] 3) Use a syringe pump to add 4.8g tetraethyl orthosilicate (TEOS) dropwise at a rate of 2ml / min. After reacting at room temperature for 30 minutes, add 0.6g triethyl phosphate (TEP) dropwise, and react for 30 minutes and then heat up to Continue to react for 12 hours at 70°C under the conditions of oil bath and condensing reflux, then add 3.112g of calcium nitrate tetrahydrate (CN), continue to react for 4 hours, cool to room temperature, and age for 18 hours;

[0051] 4) Centrifuge at 10,000r / mi...

Embodiment 2

[0058] A mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof, the preparation method of which is as follows:

[0059] (1) Preparation steps of mesoporous bioactive glass powder:

[0060] 1) Dissolve 1.6g of urea and 8g of cetylpyridinium bromide (CPB) in 192ml of deionized water, and stir well;

[0061] 2) After adding 128ml of cyclohexane, add 2g of isopropanol as a surfactant, and stir vigorously to form a uniform emulsion;

[0062] 3) Use a syringe pump to add 14.5g tetraethyl orthosilicate (TEOS) dropwise at a speed of 2ml / min. After reacting at room temperature for 30 minutes, add 0.483g triethyl phosphate (TEP) dropwise, and heat up to Continue to react for 12 hours at 70°C under the conditions of oil bath and condensing reflux, then add 2.507g of calcium nitrate tetrahydrate (CN), continue to react for 4 hours, cool to room temperature, and age for 24 hours;

[0063] 4) Centrifuge at 10,000r / min for 20min, wash with acetone...

Embodiment 3

[0070] A mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof, the preparation method of which is as follows:

[0071] (1) Preparation steps of mesoporous bioactive glass powder:

[0072] 1) Dissolve 1.333g of urea and 8g of cetylpyridinium bromide (CPB) in 200ml of deionized water, and stir evenly;

[0073] 2) After adding 120ml of cyclohexane, add 1.5g of isopropanol as a surfactant, and stir vigorously to form a uniform emulsion;

[0074] 3) Use a syringe pump to add 13.33g tetraethyl orthosilicate (TEOS) dropwise at a rate of 2ml / min. After reacting at room temperature for 30 minutes, add 0.256g triethyl phosphate (TEP) dropwise, and react for 60 minutes and then heat up to Continue to react for 12 hours at 75°C under the conditions of oil bath and condensing reflux, then add 1.329g of calcium nitrate tetrahydrate (CN), continue to react for 5 hours, cool to room temperature, and age for 24 hours;

[0075] 4) Centrifuge at 10,0...

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Abstract

The invention discloses a mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof. The method comprises: using double continuous microemulsion technology combined with sol-gel template method to prepare mesoporous bioactive glass, blending chitosan solution, polyvinyl alcohol solution, and mesoporous bioactive glass, and adding a crosslinking agent after uniform dispersion The reaction is poured into a mold, pre-frozen and shaped, and then freeze-dried. The preparation process of the composite sponge is simple, and the combination of the polycation of the chitosan material and the anion on the surface of the red blood cell membrane causes red blood cells to agglutinate, activates platelet aggregation, and activates thrombin at the same time, and the mechanical strength of the sponge is improved due to the addition of mesoporous bioactive glass , porosity and water absorption rate, it can quickly absorb liquid when it contacts the wound, and then accelerate the aggregation of platelets and red blood cells, quickly form blood clots and accumulate in the sponge network structure with multi-level pores, and finally play a hemostatic effect. The field of materials has good application prospects.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof. Background technique [0002] At present, the research on hemostatic materials at home and abroad mainly focuses on how to apply them to the local hemostasis of the human body, and it must not only be efficient and rapid, but also have certain biological safety, including degradability in the body, and no pain when removing the hemostatic material. Secondary bleeding, no toxic effects on tissues and organisms, etc. In addition, it also needs to have certain characteristics, including low cost, plasticity, portability, simple method of use, stable performance, and does not affect tissue healing. [0003] The hemostatic materials are mainly divided into two categories: biological type and chemical type. Biological hemostatic materials mainly include fibrin glue and collagen, etc., bu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/02A61L24/08A61L24/06A61L24/00
CPCA61L24/0036A61L24/02A61L24/08A61L24/06A61L24/001A61L2400/04C08L5/08C08L29/04
Inventor 陈晓峰戴翔王刚
Owner SOUTH CHINA UNIV OF TECH
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