A pharmaceutical composition for treating postpartum hemorrhage and its preparation method

A postpartum hemorrhage and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problem of lack of convenient, safe and efficient drugs for the prevention and treatment of postpartum hemorrhage, and achieve good development and application Value, less toxic side effects, less toxic effect

Active Publication Date: 2022-05-20
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of postpartum hemorrhage, to solve the technical problem of lacking the medicine of convenient, safe and efficient prevention and treatment postpartum hemorrhage and complication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take a pearl on the top of the head (Trillium tschonoskii Maxim.), grind it into fine powder, and obtain a pearl on the top of the head powder (80-100 mesh, specifically 100 mesh in this embodiment); Obtain notoginseng powder (80-100 mesh, specifically 100 mesh in this embodiment); respectively take 9 kg of pearl powder on the top of the head and 36 kg of notoginseng powder, and mix them evenly to obtain the pharmaceutical composition of this scheme.

Embodiment 2

[0023] Get 15kg of the pharmaceutical composition obtained in Example 1, and pack it into powders, 1.5g per bag, to obtain 9958 bags altogether; the patient takes orally three times a day, one bag each time.

[0024] Get 15kg of the pharmaceutical composition obtained in Example 1, fill capsules, 0.5g per capsule, and obtain 29,780 capsules in total; patients take it three times a day, 3 capsules each time.

experiment example 1

[0025] Experimental example 1: hemostatic effect of pharmaceutical composition

[0026] 1. Sample

[0027] Normal group: normal saline, daily dose 0.3ml.

[0028] Positive control group: Gongxuening Capsules (Yunnan Baiyao Group Co., Ltd., specification 0.13g / capsule, product batch number ZMA1402), prepared into a suspension of 3.38mg / ml with distilled water, with a daily dose of 0.3ml.

[0029] Composition high-dose group: take the pharmaceutical composition prepared in Example 1 and add distilled water to make a 19.5mg / ml suspension, with a daily dose of 0.3ml.

[0030] Composition low-dose group: take the pharmaceutical composition prepared in Example 1 and add distilled water to make a 9.75mg / ml suspension, with a daily dose of 0.3ml.

[0031] One bead on the top of the head group: take the one bead on the top of the head powder prepared in Example 1, add distilled water to make a suspension of 19.5 mg / ml, and the daily dose is 0.3 ml.

[0032] Notoginseng group: take t...

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical compositions, and relates to a pharmaceutical composition for treating postpartum hemorrhage, in particular to a pharmaceutical composition composed of a bead on the top of the head and Panax notoginseng and a preparation method thereof. The medicinal composition exerts its hemostatic effect through oral administration, can be used for clinical treatment of postpartum hemorrhage, has remarkable curative effect, less toxic and side effects, and has good development and application value.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical compositions and relates to a pharmaceutical composition, in particular to a pharmaceutical composition composed of a bead on the top of the head and Panax notoginseng and a preparation method thereof. Background technique [0002] Post partum hemorrhage (PPH) is a serious obstetric complication that directly affects the quality of life of surviving women, and rapid and massive blood loss can cause hemorrhagic shock, endangering the life of the parturient. The main causes of postpartum hemorrhage are uterine atony, placental factors, soft birth canal injury and coagulation dysfunction. Clinically, within 24 hours of delivery, maternal vaginal blood loss of more than 500 ml is called postpartum hemorrhage. In fact, it is more common for postpartum hemorrhage to occur within 2 to 39 days after delivery, including increased lochia, persistent vaginal bleeding, intermittent bleeding, paroxysma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61P15/00A61P7/04
CPCA61K36/896A61K36/258A61P15/00A61P7/04A61K2236/15A61K2300/00
Inventor 丁雄刘录杨竹雅马晓霞王晓珍王钺涵谭文红周志宏
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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