Anti-cancer and anti-symbiotic flora mesoporous silicon nanoparticle, and preparation method and application thereof

A nanoparticle and mesoporous silicon technology, which is applied in the direction of antibacterial drugs, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of lack of cancer cells and their symbiotic flora, complexity, etc. To achieve the effects of cancer treatment, regulation of drug release, and precise regulation of drug release

Active Publication Date: 2021-04-20
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been reports on the mechanism of the interaction between lung cancer and commensal flora, due to the complex physiological environment of lung cancer and commensal flora, there is still no reasonable and effective way to solve the problem of cancer cells and their commensal flora at the same time.

Method used

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  • Anti-cancer and anti-symbiotic flora mesoporous silicon nanoparticle, and preparation method and application thereof
  • Anti-cancer and anti-symbiotic flora mesoporous silicon nanoparticle, and preparation method and application thereof
  • Anti-cancer and anti-symbiotic flora mesoporous silicon nanoparticle, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] One, a kind of preparation method of the mesoporous silicon nano-particle of anti-cancer and anti-symbiotic flora, its steps are as follows:

[0069] (1) With dehydrated alcohol as solvent, fully dissolve active agent cetyl trimethyl ammonium bromide ( figure 1 ), the molar concentration is 0.6mM, and the volume is 30mL.

[0070] (2) Silicon-based raw material bis(triethoxysilyl)-alkyl tetrasulfide and ethyl orthosilicate ( figure 2 ) into the active agent dissolved in step (1) under vigorous stirring (stirring rate is 500rpm), add dropwise concentrated ammonia water with a mass volume ratio of 25% and a volume of 3mL, and simultaneously react for 24h. Wherein, the molar concentration ratio of bis(triethoxysilyl)-alkyl tetrasulfide to ethyl orthosilicate is 5:5, and the total molar weight is 18 mM.

[0071] (3) The solution obtained after the reaction in step (2) was centrifuged at 12000 rpm, washed with ultrapure water, dissolved in ultrapure water, reacted at 120° ...

Embodiment 2

[0100] A method for preparing mesoporous silicon nanoparticles for anti-cancer and anti-symbiotic flora, the steps are as follows:

[0101] (1) Using absolute ethanol as a solvent, fully dissolve the active agent cetyltrimethylammonium bromide with a molar concentration of 0.3mM and a volume of 30mL.

[0102] (2) adding silicon-based raw materials bis(triethoxysilyl)-alkyl tetrasulfide and ethyl orthosilicate to the active agent dissolved in step (1) under vigorous stirring (stirring rate is 500rpm), Concentrated ammonia water with a mass volume ratio of 25% and a volume of 3 mL was added dropwise, and the reaction was carried out for 24 hours. Wherein, the molar concentration ratio of bis(triethoxysilyl)-alkyl tetrasulfide to ethyl orthosilicate is 1:10, and the total molar weight is 10 mM.

[0103] (3) The solution obtained after the reaction in step (2) was centrifuged at 12000 rpm, washed with ultrapure water, dissolved in ultrapure water, reacted at 150° C. for 15 hours,...

Embodiment 3

[0110] A method for preparing mesoporous silicon nanoparticles for anti-cancer and anti-symbiotic flora, the steps are as follows:

[0111] (1) Using absolute ethanol as a solvent, fully dissolve the active agent cetyltrimethylammonium bromide with a molar concentration of 0.3mM and a volume of 30mL.

[0112] (2) adding silicon-based raw materials bis(triethoxysilyl)-alkyl tetrasulfide and ethyl orthosilicate to the active agent dissolved in step (1) under vigorous stirring (stirring rate is 500rpm), Concentrated ammonia water with a mass volume ratio of 25% and a volume of 3 mL was added dropwise, and the reaction was carried out for 24 hours. Wherein, the molar concentration ratio of bis(triethoxysilyl)-alkyl tetrasulfide to ethyl orthosilicate is 1:3, and the total molar weight is 10 mM.

[0113] (3) The solution obtained after the reaction in step (2) was centrifuged at 12000 rpm, washed with ultrapure water, dissolved in ultrapure water, reacted at 150° C. for 15 hours, ...

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Abstract

The invention discloses an anti-cancer and anti-symbiotic flora mesoporous silicon nanoparticle, and a preparation method and application thereof. The preparation method comprises the following steps of uniformly mixing bis(triethoxysilyl) alkyl tetrasulfide with ethyl orthosilicate and an active agent, and dropwise adding stronger ammonia water for reaction; etching silicon nanoparticles obtained by high-temperature reaction after separation by adopting concentrated hydrochloric acid to obtain mesoporous silicon nanoparticles; and jointly loading black phosphorus and doxycycline on the mesoporous silicon nanoparticles, and wrapping temperature-sensitive polymers to obtain the anti-cancer and anti-symbiotic flora mesoporous silicon nanoparticle. The anti-cancer and anti-symbiotic flora mesoporous silicon nanoparticle can be used for killing cancer cells and symbiotic flora in tumor positions, reduces the generation of the cancer cells through killing the cancer cells and inhibiting the cooperative effect of symbiotic inflammation on tumor inhibition, and the cancer treatment is better facilitated; a response effect is achieved on the high glutathione concentration of a tumor site, and medicine release can be effectively regulated and controlled; the black phosphorus has a photothermal effect and can effectively kill cancer cells; and at the same time, through the photothermal effect of the black phosphorus, a temperature response mechanism of the nanoparticles can be simulated, and the medicine release can be precisely regulated and controlled.

Description

technical field [0001] The invention relates to a mesoporous silicon nanoparticle, in particular to a mesoporous silicon nanoparticle for anti-cancer and anti-commensal bacteria and its preparation method and application. Background technique [0002] Cancer has become an important factor that endangers human life and health in this century, and lung cancer is one of the most common types of cancer. According to statistics, about 1.8 million people die from lung cancer every year, accounting for 18.4% of the total number of cancer deaths. With the deepening of lung cancer research, researchers have found that the commensal flora in the lung cancer site can effectively participate in the carcinogenesis of lung cancer, and the deterioration of lung cancer is mainly related to the change of the commensal flora and the up-regulation of the expression of pro-inflammatory factors. Symbiotic flora can promote the growth of lung cancer tumor cells. At the same time, tumor cells can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/14A61K47/04A61K31/65A61P35/00A61P31/04
Inventor 陈军建马尊伟贾永光王琳陈凯峰郑志雯郝丽静薛永业
Owner SOUTH CHINA UNIV OF TECH
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