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A coconut haustoria polysaccharide with antioxidant and hypoglycemic effects and preparation method thereof

A coconut and polysaccharide technology, applied in the field of biomedicine, can solve the problems of drug resistance, liver damage, fluid retention, etc., and achieve the effects of stable chemical properties, high yield, and promoting glucose consumption.

Active Publication Date: 2022-06-21
COCONUT RES INST OF CHINESE ACAD OF TROPICAL AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these methods can quickly improve the clinical symptoms of diabetic patients, long-term medication will lead to drug resistance in the body, and this type of drug will cause serious damage to the liver, kidney and other organs. For example, sulfonylurea drugs can promote insulin synthesis and secretion, But long-term use can cause side effects such as hypoglycemia and weight gain; thiazolidinediones can improve insulin sensitivity and promote glucose absorption and utilization, but long-term use can cause liver toxicity, weight gain, fluid retention and bone loss, etc. Adverse reactions

Method used

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  • A coconut haustoria polysaccharide with antioxidant and hypoglycemic effects and preparation method thereof
  • A coconut haustoria polysaccharide with antioxidant and hypoglycemic effects and preparation method thereof
  • A coconut haustoria polysaccharide with antioxidant and hypoglycemic effects and preparation method thereof

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Effect test

Embodiment 1

[0041] A preparation method of coconut sucker polysaccharide, comprising the following steps:

[0042] (1) pretreatment of raw material: coconut suction is cleaned, pulverized after drying, crosses 50 mesh sieves;

[0043] (2) the first shaking extraction: adding distilled water to the coconut aspirator after the pretreatment in step (1) according to the mass-volume ratio g / mL 1:15, shaking in a high-temperature-resistant shaker, the shaking temperature is 90 ℃, and the shaking time is 3h , to obtain the first extract;

[0044](3) second vibration extraction: filter the extract obtained in step (2), and then extract the filtered residue with distilled water by shaking again, the mass volume ratio of the filter residue and distilled water is g / mL 1:15, and the vibration temperature is 90 ° C, The shaking time is 3h, and the second extract is obtained;

[0045] (4) mixing and concentrating: the extracts obtained in step (1) and step (2) were mixed, vacuum concentrated to 25% o...

Embodiment 2

[0060] A preparation method of coconut sucker polysaccharide, comprising the following steps:

[0061] (1) the pretreatment of raw material: the coconut sucker is cleaned, pulverized after drying, crosses a 30-mesh sieve;

[0062] (2) first shaking extraction: adding distilled water to the coconut aspirator after the pretreatment in step (1) at a mass-to-volume ratio of g / mL 1:17, shaking in a high-temperature-resistant shaker, the shaking temperature was 100°C, and the shaking time was 4h , to obtain the first extract;

[0063] (3) second vibration extraction: filter the extract obtained in step (2), and then extract the filtered residue with distilled water by shaking again, the mass volume ratio of the filter residue to distilled water is g / mL 1:17, and the vibration temperature is 100 ° C, The shaking time was 4h, and the second extract was obtained;

[0064] (4) mixing and concentrating: the extracts obtained in step (1) and step (2) were mixed, vacuum concentrated to 2...

Embodiment 3

[0072] A preparation method of coconut sucker polysaccharide, comprising the following steps:

[0073] (1) the pretreatment of raw material: the coconut suction is cleaned, pulverized after drying, crosses 60 mesh sieves;

[0074] (2) first shaking extraction: adding distilled water to the coconut aspirator after the pretreatment in step (1) at a mass-to-volume ratio of g / mL 1:20, shaking in a high-temperature-resistant shaker, the shaking temperature was 110°C, and the shaking time was 5h , to obtain the first extract;

[0075] (3) the second vibration extraction: filter the extract obtained in step (2), and then extract the filtered residue with distilled water by shaking again. The shaking time was 5h, and the second extract was obtained;

[0076] (4) mixing and concentrating: the extracts obtained in step (1) and step (2) were mixed, vacuum concentrated to 25% of the total volume of the filtrate after mixing, the vacuum concentration temperature was 55° C., and the vacuu...

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Abstract

The invention provides a coconut haustoria polysaccharide with anti-oxidation and hypoglycemic effects and a preparation method thereof. The preparation method comprises the following steps: pretreatment of raw materials, vibration extraction, concentration, protein removal, decolorization, alcohol precipitation, and vacuum freeze-drying . The coconut haustoria polysaccharide prepared by the present invention has the advantages of simple operation, short process, large output, high safety, and outstanding efficacy. The prepared haustoria polysaccharide is a pure natural non-toxic plant polysaccharide, has anti-oxidation effect, and can also promote liver cells to increase glucose Consumption, which has the potential to lower postprandial blood sugar, can be used as a potential drug resource for II diabetes treatment.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a coconut inhaler polysaccharide with antioxidative and hypoglycemic effects and a preparation method thereof. Background technique [0002] Diabetes mellitus, known as "diabetes syndrome" in traditional Chinese medicine, is a global endocrine and metabolic disease characterized by elevated blood sugar levels and typical symptoms of "three more and one less", polydipsia, polyphagia, and polyuria and weight loss. Diabetes is generally divided into type I, type II, gestational diabetes and other diabetes according to the cause of the disease, among which type II diabetes accounts for more than 95%. Type II diabetes is a polygenic hereditary disease characterized by relatively insufficient insulin secretion and insulin resistance. It can directly damage islet beta cells, or activate some stress-sensitive pathways as signaling molecules, regulate the expression of related facto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P39/06A61P3/10
Inventor 张玉锋宋菲王挥张有林
Owner COCONUT RES INST OF CHINESE ACAD OF TROPICAL AGRI SCI
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