Risedronate calcium complex and preparation method thereof

A technology of calcium risedronate and risedronate, applied in the field of biomedical materials, can solve problems such as adverse reactions, low concentration threshold, etc., and achieve the effects of simple preparation method, moderate crystal growth rate, and low stress
CN112724172AInactive Publication Date: 2021-04-30SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2021-04-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a risedronate calcium complex and a preparation method thereof, the chemical formula of the risedronate calcium complex is Ca (Ris) (H2O), Ca represents calcium, Ris represents risedronate, H2O represents water, the crystal system is an orthorhombic system, the space group is P212121, and the lattice constant z is 4. The preparation method comprises the following steps: by taking calcium salt and risedronate or risedronate sodium as raw materials and deionized water as a solvent, adjusting the pH value to 3-7 by using a sodium hydroxide solution, standing at 20-200 DEG C for 12-72 hours, filtering, washing and drying to obtain a strip-shaped transparent crystal, namely the risedronate calcium complex. The preparation method disclosed by the invention is extremely simple, moderate in crystal growth speed, small in stress, good in uniformity and very complete in appearance, and has important potential application prospects in the fields of drug sustained release, targeted delivery, bone tissue repair and the like.
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Description

technical field

[0001] The invention relates to the technical field of biomedical materials, in particular to a risedronate calcium complex and a preparation method thereof. Background technique

[0002] Coordination polymers are a class of compounds formed by the combination of metal ions and organic ligands through coordination bonds. In recent years, the development of coordination polymer chemistry has endowed it with new explorations and applications in the fields of design, synthesis, structure, and performance, and has gradually become a frontier and hot topic in organic, inorganic, materials, biology, and medical disciplines. Using the principle of molecular self-assembly to design and construct complexes with novel structures, so that they have specific biological functions, has important practical significance for their wide application in the field of biomedicine.

[0003] Risedronic acid is a bisphosphonic acid small-molecule drug widely used clinically in the t...

Claims

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