Traditional Chinese medicine network pharmacology deep analysis method and system

A technology of network pharmacology and analysis method, applied in the field of in-depth analysis of traditional Chinese medicine network pharmacology, can solve problems such as poor accuracy and poor operability, and achieve the effects of improved accuracy, accurate pathway sorting, and accelerated popularization and application

Active Publication Date: 2021-04-30
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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AI Technical Summary

Problems solved by technology

[0008] Therefore, for traditional Chinese medicine, especially compound Chinese medicine, the current method enriches many pathways, has poor accuracy and poor operability, and more effective methods are still needed

Method used

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  • Traditional Chinese medicine network pharmacology deep analysis method and system
  • Traditional Chinese medicine network pharmacology deep analysis method and system
  • Traditional Chinese medicine network pharmacology deep analysis method and system

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0046] 1. Experimental materials

[0047] 1.1 Collection of disease-related targets

[0048] Use the OMIM database (https: / / omim.org), DrugBank database (https: / / go.drugbank.com / ), Genecards database (https: / / www.genecards.org / ) to search for oral ulcer-related targets, and screen The keyword was set to "Oral ulcer", and duplicate targets retrieved from different databases were screened out.

[0049] 1.2 Collection of related targets of Yatongting Dropping Pills

[0050] Use the TCMSP database (https: / / tcmspw.com / tcmsp.php) to search for the target information of the main active ingredients of Yatong Tingdrop Pills, and use "clove", "piper longum" and "borneol" as keywords to search, The oral bioavailability (OB) is greater than or equal to 30%, and the drug like index (DL) is greater than or equal to 0.18 as screening parameters, and the ingredients with biological activity and pharmacological effects reported in relevant literature are also included , to retrieve the corr...

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Abstract

The invention discloses a traditional Chinese medicine network pharmacology deep analysis method and system. The method comprises the following steps: acquiring data of related targets of diseases and traditional Chinese medicines; respectively constructing disease and traditional Chinese medicine component PPI networks, carrying out intersection operation to obtain a traditional Chinese medicine intervention disease network, and carrying out topological feature analysis on the network to obtain a core target; carrying out biological function annotation and KEGG pathway analysis on the core target; processing the degree value of a network core node by adopting a normalization method, developing and calculating an importance value tsig method of an access according to each link of core target access enrichment influence, and recreating a network for upstream and downstream of a target on an important access and an influence effect according to importance value tsig sorting of the access t; and finally, selecting a target enriched on the pathway and influencing the disease-related effect as a traditional Chinese medicine intervention disease action target. Enriched channels are more accurate and concentrated, operability is high, and a more scientific, objective and rapid analysis method and system are provided for explanation of a traditional Chinese medicine action mechanism.

Description

technical field [0001] The invention relates to the technical field of biological information, in particular to a method and system for in-depth analysis of network pharmacology of traditional Chinese medicine. Background technique [0002] Traditional Chinese medicine and compound Chinese medicine play a role in treating diseases through the synergistic effect of multiple components and multiple targets. Although the curative effect is significant, there are many active ingredients in traditional Chinese medicine, the interaction with the body is complicated, and the mechanism of action is unclear, which has become a bottleneck for the modernization of Chinese medicine and the wide application of Chinese medicine . At present, there are many methods for studying the mechanism of action of traditional Chinese medicine and compound Chinese medicine, which generally include three research modes: chemical research, target research and systems biology. Although these methods ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B40/00G16B50/10G16B20/00G16B25/20G16B15/30
CPCG16B40/00G16B50/10G16B20/00G16B25/20G16B15/30
Inventor 杨珍张艳军庄朋伟郭虹
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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