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A kind of absorbable reinforced bone implant material and its preparation method

A technology of bone implants and polylactic acid, which is applied in drug delivery, pharmaceutical formulations, prostheses, etc., can solve the problems of poor recovery effect, poor corrosion resistance, and insufficient support strength of patients, so as to promote absorbability , Function recovery is good, and the effect of reducing corrosion in the body

Active Publication Date: 2022-06-21
北京华钽生物科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the support strength of biodegradable polymer bone implant medical devices is not enough, and degradable metal materials are widely used, but pure metal materials have poor corrosion resistance and poor recovery after implantation in patients, which can easily cause other complications. disease

Method used

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  • A kind of absorbable reinforced bone implant material and its preparation method
  • A kind of absorbable reinforced bone implant material and its preparation method
  • A kind of absorbable reinforced bone implant material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of bone implant material is as follows:

[0038] 1) Prepare strontium salt, silver salt and selenium salt solution in advance, control the temperature to 30 ° C, stir and mix the strontium salt, silver salt and selenium salt solution with polylactic acid, heat up to 300 ° C and melt to obtain modified polylactic acid, cool down and cool ;

[0039] 2) Mix magnesium powder, aluminum powder, iron powder and zinc powder evenly, extrude and draw wire to form metal fibers, spray the modified polylactic acid obtained by the above steps on the surface of the metal fibers with a spray gun, and put the modified polylactic acid in an oven for 150 ℃ after spraying is completed. ℃ temperature controlled drying, cut into uniform fibers with a length of 1mm, for subsequent production and use.

Embodiment 2

[0041] The preparation method of bone implant material is as follows:

[0042]1) Prepare strontium salt, silver salt and selenium salt solution in advance, the mass percent concentration of all salt solutions is 30wt%, and the temperature is controlled to 30 ° C, and the strontium salt, silver salt and selenium salt solution are mixed with polylactic acid. The addition amount is 0.5wt% of polylactic acid, the addition amount of silver is 3wt% of polylactic acid, and the addition amount of selenium is 0.01wt% of polylactic acid, heated to 350 ℃ and melted to obtain modified polylactic acid, cooled and pulverized into particle size It is 100μm polylactic acid powder;

[0043] 2) Mix the magnesium powder, aluminum powder, iron powder and zinc powder evenly, extrude and draw wire to form metal fibers, spray the polylactic acid powder obtained by the above steps on the surface of the metal fibers with a spray gun, and the spray thickness is 3mm to ensure that the metal fibers are t...

Embodiment 3

[0045] The preparation method of bone implant material is as follows:

[0046] 1) Prepare strontium salt, silver salt and selenium salt solution in advance, the mass percent concentration of all salt solutions is 30wt%, and the temperature is controlled to 30 ° C, and the strontium salt, silver salt and selenium salt solution are mixed with polylactic acid. The addition amount is 5wt% of the polylactic acid, the addition amount of silver is 0.01wt% of the polylactic acid, and the addition amount of selenium is 5wt% of the polylactic acid. The modified polylactic acid is obtained by heating up to 350 ℃ and melting, cooling and pulverizing to a particle size of 500μm polylactic acid powder;

[0047] 2) Mix magnesium powder, aluminum powder, iron powder and zinc powder evenly, extrude and draw wire to form metal fibers, spray the polylactic acid obtained by the above steps on the surface of the metal fibers with a spray gun, and the spray thickness is 3 μm, and the quality of the...

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Abstract

The present invention provides an absorbable reinforced bone implant material and a preparation method thereof. The absorbable reinforced bone implant material of the present invention is mainly formed by mixing metal fibers and polylactic acid, wherein the polylactic acid is doped with strontium , silver and selenium salts. The enhanced bone implant material not only prevents the surface oxidation of the metal fiber through the synergistic use of polylactic acid and metal fibers, but also promotes the resorbability of the implant material, and through the doping of strontium, silver and selenium Salt promotes bone growth and reduces corrosion in the body. The patient's postoperative function recovered well. After 12 months, he could achieve the effect of being replaced by new bone, and no related complications occurred.

Description

technical field [0001] The present invention relates to the technical field of bone implants, in particular to an absorbable reinforced bone implant material and a preparation method thereof. Background technique [0002] Bioabsorbable materials refer to materials that can be degraded and absorbed in the biological environment of the body. With the continuous deepening of research on bioabsorbable materials and the interdisciplinary development of materials science, biology, and medicine, bioabsorbable materials Implantable devices used to make human body are widely used in the medical field. The development of orthopedics and trauma is inseparable from the development of materials science. In recent years, the application of absorbable materials in the field of orthopedics is mainly focused on internal fixation of fractures, and is also used in bone and cartilage tissue engineering scaffolds and drug sustained-release carriers. Bioabsorbable materials mainly include four c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/34A61L27/30A61L27/50A61L27/58A61L31/02A61L31/10A61L31/08A61L31/14D06M15/507
CPCA61L27/047A61L27/042A61L27/34A61L27/306A61L27/50A61L27/58A61L31/022A61L31/10A61L31/088A61L31/14A61L31/148D06M15/507A61L2430/02A61L2300/412A61L2300/10A61L2300/102A61L2300/104A61L2400/18A61L2420/02A61L2420/04C08L67/04
Inventor 姜培齐石培国宋总安
Owner 北京华钽生物科技开发有限公司
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