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Selenium-containing organic compound as well as preparation method and application thereof

A technology of organic compounds and compounds, applied in the field of biomedicine, can solve problems such as side effects, achieve excellent anti-tumor effects, inhibit tumor growth, and inhibit tumor cells

Active Publication Date: 2021-05-14
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, it is known that the toxicity of anticancer drugs not only acts on cancer cells, but also acts on normal cells of patients, causing side effects

Method used

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  • Selenium-containing organic compound as well as preparation method and application thereof
  • Selenium-containing organic compound as well as preparation method and application thereof
  • Selenium-containing organic compound as well as preparation method and application thereof

Examples

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preparation example Construction

[0047] According to another typical implementation of the embodiments of the present invention, a method for preparing the selenium-containing organic compound is provided, the method comprising:

[0048]

[0049] S1. The compound shown in formula IV is reacted with a chlorination reagent through chlorine substitution to obtain the compound shown in formula III;

[0050] As an optional embodiment, the chlorination reagent includes one of thionyl chloride, chlorosulfonic acid and tert-butyl hypochlorite. The ratio of the compound of formula III to thionyl chloride is 1:(1-6), the reaction temperature is 0-60° C., and the reaction time is 2-12 hours; these reaction conditions are favorable for complete chlorine substitution reaction.

[0051] S2, the compound shown in the formula III is reacted with potassium selenocyanate under the effect of catalyst to obtain the compound shown in the formula II;

[0052] specifically:

[0053] The compound represented by formula III is d...

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Abstract

The invention discloses a selenium-containing organic compound and a preparation method and application thereof. The selenium-containing organic compound comprises a compound shown in the formula I. The compound shown in the formula I has unexpected biological activity for preventing and / or treating tumors and can be effectively used for preventing and / or treating various cancers. The prepared compound as shown in the formula I has cytotoxic activity to different tumor cells, especially has good cytotoxic activity to SW480 cell strains, is superior to a control drug 5-fluorouracil, and can play a good role in inhibiting tumor cells. Animal experiment results show that the compound I has a tumor growth inhibition effect on S180-loaded mice, the tumor inhibition effect is remarkable, and the anti-tumor effect is superior to that of a control compound 5-fluorouracil under the same dosage (5mg / kg). Therefore, the compound I shows higher tumor growth inhibition efficiency than 5-fluorouracil.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a selenium-containing organic compound and its preparation method and application. Background technique [0002] Malignant tumors have become a prominent public health problem in the world today. Currently, cancer treatment methods mainly include surgical treatment, radiotherapy, chemotherapy, and biological therapy, among which chemical drug therapy is still the main treatment method. [0003] Cancer occurs as an abnormal mass of tissue in a living host organism, which receives nutrients from the host, overproliferates independently of the host, and destroys the host organism. Human organs are composed of a large number of cells. Cancer occurs when normal cells of the body become abnormal and the abnormal cells divide and multiply without check. Although genetic factors are closely related to the incidence of cancer, environmental factors also have an important impact on ...

Claims

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Application Information

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IPC IPC(8): C07D473/16A61K31/52A61P35/00
CPCA61P35/00C07D473/16
Inventor 贺贤然钟敏
Owner JIANGHAN UNIVERSITY
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