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Analytical circulating multi-dimensional liquid chromatography separation system

A multi-dimensional liquid chromatography and separation system technology, which is applied in material separation, analysis materials, measuring devices, etc., can solve undisclosed problems such as reducing the delay volume of the flow path of the chromatographic separation column array, so as to reduce the delay volume of the flow path and improve the Purity, Reduced Dissolution Diffusion and Mixing Effects

Inactive Publication Date: 2021-05-14
李宜珊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This application does not disclose how to further reduce the delay volume of the flow path after the chromatographic separation column array, so as to better improve the purity of the sample output

Method used

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  • Analytical circulating multi-dimensional liquid chromatography separation system
  • Analytical circulating multi-dimensional liquid chromatography separation system
  • Analytical circulating multi-dimensional liquid chromatography separation system

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Embodiment approach

[0031] An analytical circulation multi-dimensional liquid chromatography separation system includes an infusion unit, a sampling unit, a detection unit, a separation column array, an enrichment column array, a diluent pump, a mixer, a pipeline and a two-position multi-way valve. For the sake of brevity, the two-position multi-way valve is a two-position eight-way valve, the detection unit is an ultraviolet detector, and the sampling unit is a sampling valve or an autosampler, illustrating the best implementation mode.

[0032] A two-position ten-way valve, a two-position twelve-way valve, or a valve group composed of multiple valves, etc., can be connected into a two-position eight-way valve, which can be implemented in the same way; other connection methods can also be used to achieve the same technical effect.

[0033] The 8 ports of the 2-position 8-way valve are ①port, ②port, ③port, ④port, ⑤port, ⑥port, ⑦port, and ⑧port. The marks correspond to each other, and their number...

Embodiment

[0046] Example: A production-type circulating multidimensional liquid chromatography separation system structure

[0047] In this embodiment, the system flow path adopts (A) connection mode, the sampling unit is a sampling valve, the detection unit is an ultraviolet detector, and the enrichment column array is composed of a secondary enrichment column array and is based on the principle of an enrichment column array Operation, each level of enrichment column array has 9 enrichment columns, that is, the enrichment column array is 18 enrichment columns, which are sequentially numbered as the first enrichment column of the enrichment column array, the second enrichment column, etc., The last number is the 8th enrichment column of the enrichment column array; the separation column array has 5 separation columns, which are numbered sequentially as the 1st separation column, the 2nd separation column, etc., and the last one is the 5th separation column; Fig. The two-position eight-w...

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Abstract

The invention provides an analytical circulating multi-dimensional liquid chromatography separation system. The analytical circulating multi-dimensional liquid chromatography separation system comprises a liquid conveying unit, a sample injection unit, a detection unit, a separation column array, an enrichment column array, a diluent pump, a mixer, a pipeline and a two-position multi-way valve. According to the system, the flow path delay volume behind a chromatographic separation column can be effectively reduced, dissolution, diffusion and mixing of separated samples are reduced, the output purity of the samples is improved, and qualitative and quantitative analysis of a liquid chromatography-mass spectrometry system on complex system samples with high separation difficulty is facilitated.

Description

technical field [0001] The invention belongs to the technical field of high performance liquid chromatography separation, and relates to an analytical circulation multidimensional liquid chromatography separation system. Background technique [0002] In the LC-MS system, if the sample entering the mass spectrometer is not a monomeric compound, the reliability of mass spectrometry is very low. For this reason, it is necessary to increase the chromatographic peak capacity of the liquid phase system, improve the separation ability, and improve the purity of the sample entering the mass spectrometer for testing. [0003] Chinese patent application CN110346478A discloses a multidimensional liquid chromatography separation system based on a two-position six-way valve, which can realize circular multidimensional liquid chromatography separation. However, the output of the sample in this application must flow through a mixer with a certain volume to achieve the mixing effect. When...

Claims

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88
Inventor 李宜珊
Owner 李宜珊