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Cardiovascular disease patient DNA methylation data processing platform and method

A data processing and methylation technology, applied in genomics, used to analyze two-dimensional or three-dimensional molecular structures, instruments, etc., can solve the problem of not providing DNA methylation information for cardiovascular diseases.

Inactive Publication Date: 2021-05-14
HARBIN MEDICAL UNIVERSITY
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Problems solved by technology

[0004] Existing similar platforms including PubMeth, MethHC, MENT, etc. do not provide DNA methylation information for cardiovascular diseases

Method used

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  • Cardiovascular disease patient DNA methylation data processing platform and method
  • Cardiovascular disease patient DNA methylation data processing platform and method
  • Cardiovascular disease patient DNA methylation data processing platform and method

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Embodiment Construction

[0037] The technical solution of the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0038] The present invention is a multifunctional network platform, which is constructed by using HTML5+bootstrap4+PHP+MySQL+jbrowser+R. Web pages based on bootstrap4 can be adapted to a variety of devices and browsers, and dynamic interactions between web pages and users can be achieved based on PHP. MySQL is the current mainstream database platform with good stability, security and running speed. jbrowser provides a genome methylation browser that can interact dynamically; R language analyzes and processes the acquired tools and builds web tools.

[0039] 1. Methylation microarray data and preprocessing of patients with cardiovascular disease:

[0040] Cardiovascular disease methylation data were systematically refined from the GEO database (before October 2019) using the following keyword combinations: (c...

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Abstract

The invention discloses a cardiovascular disease patient DNA methylation data processing platform and method. The platform comprises a search module, a browsing module, a disease detail module and a tool module. The invention further discloses a cardiovascular disease patient DNA methylation data processing method. The platform is built in the Internet, and a user can look up differential methylation genes of patients with cardiovascular diseases or which cardiovascular disease the methylation level difference of a certain gene is most significant in the platform; meanwhile, the gene methylation levels of patients with different cardiovascular diseases under different sites in the genome can be visually checked through an online visual browser; known treatment drugs of different cardiovascular diseases can be visually checked through the interactive network tool, so that a user can carry out prediction analysis based on a network; and several online tools also allow the user to upload own data to enter a network platform for analysis and processing. The platform can greatly improve the current understanding of cardiovascular diseases, and becomes a timely and valuable resource.

Description

technical field [0001] The invention belongs to the technical field of medical data processing, and relates to a DNA methylation data processing platform and method for patients with cardiovascular diseases. Background technique [0002] Cardiovascular disease (CVD) is a series of diseases affecting the heart and blood vessels, including coronary artery disease, angina pectoris, heart failure, rheumatic heart disease, pulmonary hypertension and other diseases. Among them, coronary heart disease is caused by narrowing of the coronary arteries, resulting in an imbalance between the functional demands of the heart and the ability of the coronary arteries to supply blood and oxygen. Congenital heart disease is usually caused by abnormal development of the heart and circulatory system before birth. Pulmonary artery disease Hypertension refers to a hemodynamic and pathophysiological state in which pulmonary artery pressure rises above a certain threshold, leading to right heart fa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B15/30G16B20/20
CPCG16B15/30G16B20/20
Inventor 王理赵红颖许昊天
Owner HARBIN MEDICAL UNIVERSITY
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