Ti3C2Tx composite material, preparation method thereof, SERS substrate and detection method of nitrofurantoin and ofloxacin

A composite material, nitrofurantoin technology, applied in the fields of nanotechnology, analytical materials, material excitation analysis for materials and surface science, can solve problems such as difficulty in meeting the needs of on-site rapid inspection, easy agglomeration, poor stability, etc., to achieve high practical The effect of application value, good selectivity and high reproducibility

Active Publication Date: 2021-05-28
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Metal sol substrate is currently the most commonly used SERS substrate. It is metal, which is easy to prepare and economical. However, it is easy to agglomerate and has poor stability, which is difficult to meet the needs of on-site rapid inspection.

Method used

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  • Ti3C2Tx composite material, preparation method thereof, SERS substrate and detection method of nitrofurantoin and ofloxacin
  • Ti3C2Tx composite material, preparation method thereof, SERS substrate and detection method of nitrofurantoin and ofloxacin
  • Ti3C2Tx composite material, preparation method thereof, SERS substrate and detection method of nitrofurantoin and ofloxacin

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Effect test

Embodiment 1

[0057] Take 3mL of Ti with a concentration of 1.0mg / mL 3 C 2 T x The nanosheet dispersion (the number of layers is 1-10 layers, purchased from Hangzhou Namao Technology Co., Ltd.) was mixed evenly with 3 mL of single-stranded DNA with a concentration of 1.0 mg / mL (single-stranded DNA was salmon sperm DNA, purchased from Beijing Soleibao Technology Co., Ltd., heated in a water bath at 95°C for 5 minutes before use, and cooled rapidly), ultrasonicated in an ice-water bath for 30 minutes, diluted with water to 80 mL, stirred magnetically for 30 minutes, centrifuged at 8500 rpm for 10 minutes, and washed with deionized water for 3 times , redispersed in 80mL water to obtain Ti 3 C 2 T x / DNA dispersion.

[0058] To the above Ti 3 C 2 T x Add 1.35mL 1.0% Tween-20 to the DNA dispersion and stir for 30min, then slowly add 9.0mL AgNO with a concentration of 20mM 3 Solution, after continuous stirring for 1 h, slowly add 9.0 mL of ascorbic acid solution with a concentration of ...

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Abstract

The invention discloses a Ti3C2Tx composite material, a preparation method thereof, an SERS substrate and a detection method of nitrofurantoin and ofloxacin. The Ti3C2Tx composite material comprises Ti3C2Tx and silver nanoparticles loaded on the Ti3C2Tx through nucleotide chains. The Ti3C2Tx composite material effectively overcomes the problems that an existing metal sol substrate is prone to agglomeration and poor in stability, can be used for manufacturing an SERS substrate for rapid quantitative analysis of nitrofurantoin or ofloxacin or simultaneous rapid quantitative detection of two antibiotics, namely nitrofurantoin and ofloxacin, has the advantages of being good in selectivity, high in reproducibility, easy to operate and the like, is helpful for solving the problem of simultaneously and quickly detecting various antibiotics in food (especially aquatic products), cosmetics or other products, and has very high practical application value.

Description

technical field [0001] The invention belongs to the technical field of aquatic product detection, in particular to Ti 3 C 2 T x Composite materials and their preparation methods, SERS substrates, detection methods for nitrofurantoin and ofloxacin. Background technique [0002] Nitrofuran and quinolone antibiotics are the two most common prohibited / restricted drugs, and these two types of antibiotics may exist in aquatic products at the same time. To establish a highly efficient, accurate and economical nitrofuran and quinolone antibiotic simultaneously Quantitative analysis methods are of great importance for food safety. [0003] At present, the detection methods of nitrofuran and quinolone antibiotics in aquatic products are mostly high-performance liquid chromatography, which is time-consuming, complicated, and expensive, and it is difficult to meet the needs of on-site rapid detection by regulatory authorities. SERS (Surface Enhanced Raman Scattering) technology has ...

Claims

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Application Information

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IPC IPC(8): G01N21/65B22F1/00B22F9/24B82Y30/00B82Y40/00
CPCG01N21/658B22F9/24B82Y30/00B82Y40/00B22F1/054
Inventor 张卓旻余忠宁李攻科
Owner SUN YAT SEN UNIV
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