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Biomarkers for evaluating early colorectal cancer

A biomarker, colorectal cancer technology, applied in biochemical equipment and methods, microbial determination/examination, instruments, etc., can solve problems affecting the treatment and prognosis of colorectal cancer patients

Inactive Publication Date: 2021-06-08
QINGDAO MEDINTELL BIOMEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current studies have confirmed that colorectal cancer cells metastasize tumors by evading the body's immune surveillance, which seriously affects the treatment and prognosis of colorectal cancer patients

Method used

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  • Biomarkers for evaluating early colorectal cancer
  • Biomarkers for evaluating early colorectal cancer
  • Biomarkers for evaluating early colorectal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] Example 1 Screening of differentially expressed genes associated with colorectal cancer

[0117] 1. Sample source

[0118] Download the sequencing data of the PRJEB27536 data set from SRA and the colorectal cancer gene expression data from TCGA. The sample size is normal tissue: polyp tissue: colorectal cancer TNM1: TNM2: TNM3: TNM4 = 50:21:52:123:89: 44.

[0119] 2. Data processing

[0120] The raw data from the SRA database was processed and quality-controlled using fastq software, and the obtained cleandata was compared to the human reference genome using ICGC software (GRCh38.d1.vd1), and the bam file was quantified using htseq software.

[0121] quantitative mode: intersection-nonempty;

[0122] Quantitative standard type: gene_id;

[0123] Chain specificity: non-specific.

[0124] The expression level files are merged according to the gene ID to construct an M*N gene expression level matrix. The value in the i-th row and j-column in the gene expression level ...

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PUM

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Abstract

The invention discloses biomarkers for evaluating early colorectal cancer, and particularly relates to biomarkers RRP1B, CDH17, RP11-77K12.9, SLC5A8 and / or AC009237.11. Compared with a normal control, the expression of RRP1B in early colorectal cancer is up-regulated, the expression of CDH17, RP11-77K12.9, SLC5A8 and AC009237.11 in early colorectal cancer is down-regulated, and a diagnosis efficiency analysis result shows that the biomarkers have higher sensitivity and specificity when applied to diagnosis of the early colorectal cancer.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a biomarker for evaluating early colorectal cancer. Background technique [0002] Human colorectal cancer (CRC) is one of the most common digestive system malignancies in the world. Statistics from the World Cancer Trend Analysis show that colorectal cancer is the third most common malignant tumor in men and the second most common malignant tumor in women, which seriously threatens human health and life (Siegel RL, Miller K D, Fedewa S A, et al a1. Colorectal cancer statistics [J]. CA Cancer J C1in, 2017, 67(3): 177-193.). It is characterized by high recurrence rate and high mortality rate, and more than 600,000 people die of colorectal cancer every year in the world (Brenner H, Kloor M, PoxC P. Colorectal cancer [J]. Lancent, 2014, 383 (9927): 1490-1502 .). About 20% of patients have metastases at the time of first diagnosis (Riihimaki M, Hemminki A, Sundquist J, et a1.Patterns of met...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11G01N33/574
CPCC12Q1/6886C12Q2600/158G01N33/57419G01N33/57484
Inventor 杨承刚刘乐凯
Owner QINGDAO MEDINTELL BIOMEDICAL CO LTD
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