Composite traditional Chinese medicine patch for treating epidermis thickening and pruritus dermatosis

A technology for itchy skin diseases and traditional Chinese medicine stickers, applied in skin diseases, drug combinations, pharmaceutical formulations, etc., can solve the problems of discontinued use, easily sensitized skin, thin and atrophied skin, etc.

Pending Publication Date: 2021-06-11
上海奥茵特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the disadvantage is that these varieties, such as Piyanning tincture and these two patches, are prone to allergies and patients often have to discontinue use
Analyzing the reasons, first, these varieties contain salicylic acid ingredients, which are irritating to the skin and are also prone to skin allergies; second, the pressure-sensitive adhesive ingredients contained in the patch contain allergenic ingredients
In addition, because these varieties all contain glucocorticoids, long-term use is p

Method used

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  • Composite traditional Chinese medicine patch for treating epidermis thickening and pruritus dermatosis
  • Composite traditional Chinese medicine patch for treating epidermis thickening and pruritus dermatosis
  • Composite traditional Chinese medicine patch for treating epidermis thickening and pruritus dermatosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A compound traditional Chinese medicine patch for treating epidermis thickening and pruritus skin diseases, each raw material is prepared according to the following weight parts and weight percentages: each of Radix Cortex Radix and Sophora flavescens contains 18 weight units (the same below); 13; dark plum 7; borneol 0.8% (plaster weight percentage, the same below); lanolin 13%; pressure-sensitive adhesive 77.1%. After crushing the components of Chinese medicinal materials (except borneol) into 20 meshes, infiltrate with proportional ethanol, percolate, and recover ethanol under reduced pressure to concentrate into a thick paste with a specific gravity of 1.1; Put lanolin (according to the ratio of thick paste / lanolin = 0.7) and borneol into the average value emulsification pot, heat to 65°C, carry out average value emulsification and fully mix to form a suspension into a paste, then cool to 48°C, and then mix with pressure sensitive The glue is fully mixed into a plas...

Embodiment 2

[0042] A compound traditional Chinese medicine patch for treating epidermis thickening and itching skin diseases, preferably: each raw material is prepared according to the following weight parts and weight percentages: each content of white fresh skin, flavescens, and raw licorice is 21 weight units (the same below) 14.5 each of Habitat, Salvia, Angelica, ebony 8.5; Borneol 1.1% (plaster weight percentage, the same below); Lanolin 18%; Pressure-sensitive adhesive 59.3%. After the components of Chinese herbal medicines (except borneol) are crushed into 20 meshes, they are infiltrated with proportional ethanol, percolated, and recovered under reduced pressure to concentrate the ethanol to a thick paste with a specific gravity of 1.2; Put lanolin (according to the ratio of thick cream / lanolin = 1.2) and borneol into the average value emulsification pot, heat to 75°C, carry out average value emulsification and fully mix to form a suspension into a paste, then cool to 58°C, and the...

Embodiment 3

[0044] A compound traditional Chinese medicine patch for treating epidermal thickening and pruritus skin diseases, more preferably: each raw material is prepared according to the following weight parts and weight percentages: each content of white fresh bark, Sophora flavescens, and raw licorice is 20 weight units (the same below ); Rehmannia, Salvia, Angelica each 14, ebony 8; Borneol 1% (plaster weight percentage, the same below); Lanolin 10%; Pressure sensitive adhesive 79%. After crushing the components of Chinese herbal medicines (except borneol) into 20 meshes, infiltrate with proportional ethanol, percolate, and recover ethanol under reduced pressure to concentrate into a thick paste with a specific gravity of 1.3; Put lanolin (according to the ratio of thick cream / lanolin = 1) and borneol into the average value emulsification pot, heat to 80°C, carry out average value emulsification and fully mix to form a suspension into a paste, then cool to 53-55°C, and then mix with...

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Abstract

A composite traditional Chinese medicine patch for treating epidermis thickening and pruritus dermatosis belongs to an external Chinese patent medicine preparation, and is prepared by the following steps: crushing cortex dictamni, radix sophorae flavescentis, radix rehmanniae, angelica sinensis, salvia miltiorrhiza, raw liquorice, dark plum and the like, extracting, percolating, concentrating and the like to prepare thick paste, mixing the thick paste with borneol and matrix lanolin to obtain finished paste, and filling the finished paste with a traditional Chinese medicine preparation for treating epidermis thickening and pruritus dermatosis; mixing the finished paste with a pressure-sensitive acrylic polyurethane adhesive, coating a non-woven fabric backing with the mixture, carrying out hot drying, cutting the mixture into blocks, covering the blocks with protective paper, carrying out packaging, carrying out cobalt-60 disinfection and the like so as to prepare the composite traditional Chinese medicine patch. In order to solve the problems that the effect of externally applied liniments and patches for treating epidermis thickening and itching skin diseases (mainly including neurodermatitis (limitation), chronic eczema (moss-like change), psoriasis (common type) and the like) is limited or side effects are caused due to hormone contained, a pure traditional Chinese medicine formula is adopted in the development of the product, and the process is optimized; and a patch is prepared by matching with a safe pressure-sensitive adhesive with excellent performance, so as to provide an externally applied drug variety with a more accurate and safer effect for the treatment of the skin diseases.

Description

[0001] The invention relates to an improved compound traditional Chinese medicine patch for treating epidermis thickening and pruritus skin diseases, and belongs to the technical field of pharmaceutical preparations for external use. [0002] technical background [0003] Thickened epidermis pruritic dermatosis is a type of skin disease characterized by significant skin itching and thickened epidermis. Common neurodermatitis, chronic eczema, lichen planus, and pruritus are common. Some of these diseases are mainly characterized by pruritus without primary inflammatory pathological changes such as neurodermatitis (also known as lichen simplex chronica), but small inflammatory papules usually appear during the development of the disease; There may be a pathological basis of primary allergy such as chronic eczema, lichen planus and psoriasis; and simple pruritus. In the category of inflammatory epidermal thickening skin diseases, long-term chronic skin itching and thickening of th...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K36/804A61K9/70A61P17/00A61P17/04A61P17/06A61P25/00A61K31/045
CPCA61K45/06A61K36/75A61K36/489A61K36/484A61K36/804A61K36/232A61K36/537A61K31/045A61K36/736A61K9/7069A61P17/00A61P17/04A61P17/06A61P25/00A61K2300/00
Inventor Z·林奇
Owner 上海奥茵特生物科技有限公司
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