Micro-needle transdermal drug delivery system based on micro-piezoelectric pump thermal driving coupling accurate control

Abstract

A micro-needle transdermal drug delivery system based on micro-piezoelectric pump thermal driving coupling accurate control comprises a micro-piezoelectric pump, a pipeline, a circular-truncated-cone-shaped hollow micro-needle, a wire, a power source, a first drug storage cavity and a second drug storage cavity. The micro-piezoelectric pump is composed of a piezoelectric vibrator and a micro-piezoelectric pump cavity; a V-shaped liquid inlet hole is formed in the side portion of the micro-piezoelectric pump cavity; and a Y-shaped liquid outlet hole is formed in the bottom of the micro-piezoelectric pump cavity. According to the micro-needle transdermal drug delivery system based on micro-piezoelectric pump thermal driving coupling accurate control, the flow of liquid medicine can be accurately controlled, the conical valveless inlet (V-shaped) outlet (Y-shaped) liquid hole can prevent a large amount of liquid medicine from flowing back, the speed of the liquid medicine entering the micro-needle end can be increased; the circular-truncated-cone-shaped hollow micro-needle is adopted; the needle tip can be prevented from being broken and left in a living body; and the piezoelectric plate and the metal heating structure are matched to control the micro-piezoelectric pump, so that the pump works stably, and the dosing efficiency can be ensured.

Description

technical field [0001] The invention relates to a device in the field of biomedicine, in particular to a microneedle transdermal drug delivery system based on micro piezoelectric pump heat-driven coupling and precise control. Background technique [0002] In recent years, with the continuous advancement of MEMS (Micro-Electro-Mechanical Systems) technology, the use of MEMS technology to realize the miniaturization of micro piezoelectric pumps has developed rapidly. However, the current microneedle transdermal drug delivery system is still lacking in operability, size, and manufacturing process. For example, some microneedle drug delivery systems only consist of a flexible cavity and hollow microneedles, which is difficult Overcome the pressure difference between the inside and outside of the human body, and the control of the liquid medicine is not precise; some microneedle drug delivery systems are composed of a pressure propulsion system and a hollow microneedle, which can...

AI Technical Summary

Problems solved by technology

When the system is working, the coupling between the micro-piezoelectric pump and the metal heating structure can precisely control the flow rate of the liquid medicine. The conical valveless inlet and outlet holes can not only prevent a large amount of liquid medicine from flowing back, but also accelerate the liquid medicine entering the microneedle end, solving the problem of drug flow. The problem of inaccurate liquid flow control; the piezoelectric sheet and the heater provide the driving force to promote the flow of the liquid medicine at the same time, which can overcome the pressure difference between the inside and outside of the body when the liquid medicine enters the organism through the microneedle

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