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Imaging method and device combining k space and image space reconstruction

An imaging method and technology of image space, which are applied in the direction of using nuclear magnetic resonance imaging system for measurement, magnetic variable measurement, magnetic resonance measurement, etc. problem, to achieve the effect of improving the net acceleration effect and speeding up the collection speed

Active Publication Date: 2021-06-22
ZHEJIANG UNIV
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Problems solved by technology

[0010] The purpose of the present invention is to solve the problems in the prior art that multi-frame imaging reconstruction cannot be self-calibrated, and the reconstructed image has potential artifacts, and the speed-up effect is greatly limited, and provides a fast imaging method combining k-space and image space reconstruction (The English name is joint K-space and Image-space Parallel Imaging, which can be referred to as the KIPI method in the future) and the device, which can recover accurate images from highly undersampled k-space data

Method used

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Embodiment

[0071] 1. MRI experiment

[0072] All phantom experiments and human experiments were performed on a 3 Tesla (T) Siemens scanner (MAGNETOM Prisma, Siemens Healthcare, Erlangen, Germany) using a 64-channel receiver head coil. The phantom consists of a flask filled with 2% agarose gel and two test tubes. One tube was filled with 10% bovine serum albumin (BSA) dissolved in phosphate buffered saline (PBS) and the other tube was filled with 5% bovine serum albumin also dissolved in PBS. Human studies were approved by the local institutional review board.

[0073] The sequence used was the CEST imaging sequence, and the measured MRI parameter was the magnitude of the amide proton transfer effect.

[0074] For the phantom, the CEST scan uses a 1.0s long, 2μT saturation pulse, and then uses a fat-suppressed axial 2D multi-spin echo (TSE) sequence readout, and the acquisition parameters are TE=6.7ms; TR=3s; FA=90; FOV=212×186mm 2 ;Resolution=2.2×2.2mm 2 ; Slice thickness = 5 mm; Ac...

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Abstract

The invention discloses an imaging method and device combining k space and image space reconstruction, and belongs to the field of magnetic resonance imaging. According to the method, firstly, a k space parallel imaging method is used for reconstructing an undersampling image frame with an automatic calibration signal, wherein the undersampling image frame is obtained in multi-frame imaging needed by magnetic resonance parameter measurement of a measured object; and then, for other under-sampling image frame data without an automatic calibration signal, carrying out reconstruction in an image space. According to the method, the accurate sensitivity graph required by the SENSE method is generated from the undersampled data, and additional acquisition is not needed. According to the method, an image which is almost consistent with a traditional GRAPPA method is generated, and no obvious artifact exists; however, the speed of the method is four times or above that of the traditional GRAPPA method. The method serves as a self-calibration reconstruction method, does not need a full sampling frame, and is particularly suitable for accelerating three-dimensional (3D) multi-frame magnetic resonance imaging.

Description

technical field [0001] The invention belongs to the field of magnetic resonance imaging, and can realize fast acquisition for the measurement of magnetic resonance parameters requiring multiple frames of image data. Background technique [0002] Magnetic resonance imaging (MRI) can be used to measure tissue including nuclear spin density, longitudinal relaxation time (T1), transverse relaxation time (T2), apparent diffusion coefficient (ADC), cerebral blood flow rate, magnetization transfer rate, etc. parameter. Signal sources for these parameters can be the nuclei of endogenous compounds present in the organism (e.g. 1 H), can also be exogenous substances or tracers. Direct quantification of MRI parameters of tissue can provide more valuable clinical information on various pathologies in neurological, musculoskeletal, hepatic, and cardiac imaging. [0003] Imaging techniques for measuring these parameters include relaxation time imaging, diffusion imaging, perfusion imag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/56
CPCG01R33/56G01R33/5611G01R33/5605G01R33/5608
Inventor 张祎祖涛孙毅吴丹
Owner ZHEJIANG UNIV
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