In-situ cleaning method for ion migration tube

Abstract

The invention discloses an in-situ cleaning method for an ion migration tube. According to the method, when the ion migration tube is cleaned, the ion migration tube does not need to be disassembled, cleaning liquid is injected from one end of the ion migration tube and then discharged from the other end through carrier gas or drift gas used by a mobility spectrometer, and in-situ cleaning of the ion migration tubes is achieved. The method is simple and convenient, time is saved, and the method can be used for cleaning or daily maintenance of the polluted ion migration tubes.

Description

technical field [0001] The invention relates to an in-situ cleaning method for an ion transfer tube. Background technique [0002] Ion mobility spectrometry is widely used in the detection of chemical poisons, explosives, and drugs due to its fast analysis speed, high sensitivity, small size, and simple operation. In addition, because ion mobility spectrometry can separate isomers, it is often used in conjunction with mass spectrometry to detect biological samples. In recent years, the application of ion mobility spectrometry has penetrated into the field of medical diagnosis, such as the detection of small molecular metabolites in exhaled breath, anesthetics in blood, etc. However, when ion mobility spectrometry detects complex samples or is used for on-site detection, it is prone to signal saturation memory effect. When the transfer tube is not used for a long time, it is also easy to be contaminated. When it is used again, there will generally be many unknown peaks in t...

AI Technical Summary

Problems solved by technology

However, when ion mobility spectrometry detects complex samples or is used for on-site detection, it is easy to produce signal saturation memory effect

When the transfer tube is not used for a long time, it is also easy to be contaminated. When it is used again, there will generally be many unknown peaks in the spectrum, which will affect the qualitative and quantitative detection.

Since the migration spectrometer works at atmospheric pressure, the residual and neutralized ions in the sample are easily adsorbed on the inner wall of the transfer tube, and it is difficult to clean them directly with drift gas.

In addition, the structure of the transfer tube is complex, generally using a stacked structure, with many and delicate parts, and it is troublesome to disassemble and clean directly

Especially the polytetrafluoroethylene insulation commonly used in the transfer tube, after the transfer tube is heated and used, it will expand and deform, and it is often difficult to reassemble after disassembly and washing, or the sealing performance will become poor after reassembly

[0003] The patent "an ion transfer tube that is easy to disassemble and clean" applied by Mi Yujun was authorized on January 4, 2019. Its technical feature is that the inner tube and outer tube of the ion transfer tube used for the ion transfer number experiment are integrally formed The inner plug and the outer sheath are connected and sealed, which is convenient for the disassembly and cleaning of the inner tube, but this method still needs to disassemble the ion transfer tube for cleaning, and then restore it in assembly, which is still not convenient enough

The patent applied by the First Research Institute of the Ministry of Public Security "-a purification treatment method for ion mobility spectrometry sampling strips", the sampling strips that have been sampled and tested are treated with a dissolving solvent, a cleaning solvent and pure water, and then dried to restore their performance, but does not involve cleaning within the transfer tube

[0004] In addition, when the transfer tube is working, it is necessary to form a uniform electric field in the transfer tube and apply pulses to control the ion gate, so the connection of the conductive wires on the transfer tube is complicated, and generally needs to be used together with heating sheets and insulation materials. It is also more troublesome to remove the migration spectrum from the whole machine

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