Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Face filling agent containing cross-linked glucan and preparation method thereof

A technology of cross-linked dextran and filler, applied in medical science, prosthesis, etc., can solve problems such as pain, skin depression, local redness and swelling, and achieve mild reaction, long-lasting filling effect and good tissue compatibility. Effect

Inactive Publication Date: 2021-06-29
红色未来科技(北京)有限公司
View PDF11 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the direction of differentiation of adipose stem cells after transplantation is not controlled, and the survival rate is low. Some of the unviable fat will be excreted through metabolism, and the rest may liquefy. The patient's skin will be sunken, and there may be bleeding Fluid, pus and pain, local redness and swelling

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Face filling agent containing cross-linked glucan and preparation method thereof
  • Face filling agent containing cross-linked glucan and preparation method thereof
  • Face filling agent containing cross-linked glucan and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The facial filler of this embodiment includes 50 parts of cross-linked dextran, 30 parts of autologous fat stem cells, 5 parts of polymethyl methacrylate, and 15 parts of 0.9 wt% physiological saline for injection.

[0033] The preparation method of the facial filler of the present embodiment comprises the steps:

[0034] (1) Add cross-linked dextran with a molecular weight of 800,000 to 1 million into ultrapure water with 100 times the volume of cross-linked dextran, stir for 1 hour, sterilize at 120°C for 20 minutes to obtain cross-linked dextran and ultrapure A mixture of water, the ultrapure water in the mixture is filtered to obtain the processed cross-linked dextran;

[0035] (2), using the same volume of ultrapure water as the normal saline for injection in step (1) to repeatedly infiltrate the processed cross-linked dextran 3 times, and then filter the normal saline for injection to obtain the processed cross-linked dextran ;

[0036] (3) Put the fat liquid su...

Embodiment 2

[0043] The facial filler of this embodiment includes 40 parts of cross-linked dextran, 50 parts of autologous fat stem cells, 3 parts of polymethyl methacrylate, and 7 parts of 0.8 wt% physiological saline for injection.

[0044] The preparation method of the facial filler of the present embodiment comprises the steps:

[0045] (1) Add cross-linked dextran with a molecular weight of 1.5-2 million to ultrapure water with 1000 times the volume of cross-linked dextran, stir for 3 hours, sterilize at 120°C for 20 minutes to obtain cross-linked dextran and ultra-pure A mixture of water, the ultrapure water in the mixture is filtered to obtain the processed cross-linked dextran;

[0046](2), using the same volume of ultrapure water as the normal saline for injection in step (1) to repeatedly infiltrate the processed cross-linked dextran 3 times, and then filter the normal saline for injection to obtain the processed cross-linked dextran ;

[0047] (3) Put the fat liquid sucked out...

Embodiment 3

[0053] The facial filler of this embodiment includes 20 parts of cross-linked dextran with a molecular weight of 500,000-800,000, 50 parts of autologous fat stem cells, 10 parts of polymethyl methacrylate, and 20 parts of 0.9 wt% injection saline. Its preparation method is identical with embodiment 2.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medical fat transplantation, and particularly relates to a face filling agent containing adipose-derived stem cells and a preparation method thereof, and the face filling agent comprises the following components in parts by weight: 20-180 parts of cross-linked glucan, 5-120 parts of adipose-derived stem cells, 1-50 parts of polymethyl methacrylate and 10-150 parts of normal saline for injection. The facial filling agent has the beneficial effects that the facial filling agent uses cross-linked glucan as a main filling material, so that the survival rate of adipose-derived stem cells can be ensured, adipogenic differentiation of the adipose-derived stem cells can be induced, the tissue compatibility is better, the maintenance time is longer, the effect is more natural, the postoperative reaction is slight, and the lasting filling effect can be achieved.

Description

technical field [0001] The invention belongs to the technical field of medical fat transplantation, and in particular relates to a facial filler containing cross-linked dextran and a preparation method thereof. Background technique [0002] With the improvement of people's material living standards, more and more people choose to use facial injection filling method to reshape facial features. At present, autologous fat filling and fat stem cell filling are generally used. The autologous fat filled with autologous fat is to absorb excess subcutaneous fat cells from certain parts of the human body, and then the aspirated mixture is purified, injected with drugs to obtain compound fat particles, and the complete granular fat cells are selected and transplanted into the body by injection. The part that needs to be filled with fat. Autologous fat filling is widely used in facial filling surgery because of its small damage to the donor site, easy access, good tissue compatibilit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/20A61L27/38A61L27/36A61L27/16A61L27/56A61L27/50
CPCA61L27/3834A61L27/20A61L27/16A61L27/50A61L27/3691A61L27/3687A61L27/56C08L5/02
Inventor 李长明
Owner 红色未来科技(北京)有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com