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Gold-silver core-shell nanoparticles and method for applying gold-silver core-shell nanoparticles to electrochemical alternating-current impedance ultra-sensitive chiral recognition

A gold nanoparticle and nanoparticle technology, applied in the field of electrochemical AC impedance ultrasensitive chiral recognition, gold@silver core-shell nanoparticles, can solve the problems of poor sensitivity and inability to identify enantiomers, and achieve high sensitivity , the effect of improving stability

Pending Publication Date: 2021-07-06
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the main disadvantage of colorimetric chiral recognition is its poor sensitivity and inability to effectively identify enantiomers at low concentrations

Method used

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  • Gold-silver core-shell nanoparticles and method for applying gold-silver core-shell nanoparticles to electrochemical alternating-current impedance ultra-sensitive chiral recognition
  • Gold-silver core-shell nanoparticles and method for applying gold-silver core-shell nanoparticles to electrochemical alternating-current impedance ultra-sensitive chiral recognition
  • Gold-silver core-shell nanoparticles and method for applying gold-silver core-shell nanoparticles to electrochemical alternating-current impedance ultra-sensitive chiral recognition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation of gold@silver core-shell nanoparticles includes the following steps:

[0041](1) Add 1mL 0.025mol / L tetrachloroauric acid trihydrate solution to 98mL water and stir, the solution is heated to boiling, add 1mL 0.07mol / L sodium citrate solution, the solution changes from light yellow to dark red, and Continue stirring at high temperature for 10 minutes to prepare gold nanoparticles.

[0042] (2) Take 20mL of the gold nanoparticles prepared in step (1) in a beaker, heat the solution to boiling, add 1mL of 0.07mol / L sodium citrate solution and 20μL of 50mmol / L silver nitrate solution, the solution changes from dark red to Orange color, continue to stir at high temperature for 10 minutes to prepare gold@silver core-shell nanoparticles.

[0043] attached figure 1 It is a transmission electron microscope image of gold nanoparticles. It can be seen from the figure that the gold nanoparticles are well dispersed and the size distribution is uniform. The average...

Embodiment 2

[0045] The preparation of gold@silver core-shell nanoparticles / tryptophan composite modified electrode includes the following steps:

[0046] (1) Take 2mL of the gold@silver core-shell nanoparticles prepared in Example 1, add 0.5mL of 0.1nmol / L L-tryptophan and D-tryptophan solutions respectively, and let it stand at room temperature for 15min to react. Gold@silver core-shell nanoparticles / L-tryptophan complexes and gold@silver core-shell nanoparticles / D-tryptophan complexes were prepared.

[0047] (2) Use a pipette gun to pipette 5 μL drops of gold@silver core-shell nanoparticles / L-tryptophan complex and gold@silver core-shell nanoparticles / D-tryptophan complex prepared in step (1). Coated on the surface of glassy carbon electrode and dried under infrared lamp for 15min, the gold@silver core-shell nanoparticle / L-tryptophan composite modified electrode and gold@silver core-shell nanoparticle / D-tryptophan can be prepared Composite modified electrodes.

[0048] The two gold@si...

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Abstract

The invention belongs to the technical field of nano material preparation and molecular recognition, and relates to gold-silver core-shell nanoparticles and a method for applying the gold-silver core-shell nanoparticles to electrochemical alternating-current impedance ultra-sensitive chiral recognition. The method comprises the following steps of: preparing gold nanoparticles, preparing gold-silver core-shell nanoparticles, preparing a gold-silver core-shell nanoparticle / tryptophan compound, preparing a gold-silver core-shell nanoparticle / tryptophan compound modified electrode, and carrying out electrochemical alternating-current impedance ultra-sensitive chiral recognition on a tryptophan enantiomer. The method has the beneficial effects that the prepared gold-silver core-shell nanoparticle / tryptophan compound can be used for ultra-sensitive chiral recognition of tryptophan enantiomers, and effective electrochemical impedance recognition of tryptophan enantiomers with the concentration as low as 0.1 nmol / L can also be achieved.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation and molecular recognition, and specifically relates to a gold@silver core-shell nanoparticle and a method for electrochemical AC impedance ultrasensitive chiral recognition thereof. Background technique [0002] Chirality and chiral analysis are of great significance in modern chemistry and chemical technology, so the development of simple and intelligent enantiomeric recognition devices has become a research hotspot in life science and many other related fields. Amino acids are important enantiomeric compounds, and their different configurations play different or even opposite roles in life sciences. Therefore, chiral recognition of amino acid enantiomers is of great significance in life sciences. At present, the most common methods for enantioselective identification mainly include chromatography and spectroscopy, but these two methods are costly and time-consuming. Therefore,...

Claims

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Application Information

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IPC IPC(8): G01N27/327
CPCG01N27/3278
Inventor 孔泳吴姗姗王慧吴大同
Owner CHANGZHOU UNIV
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