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A kind of control method of magnetic bead purification equipment

A technology for control methods and purification equipment, applied in chemical instruments and methods, magnetic separation, solid separation, etc., to achieve sufficient movement, high separation efficiency of magnetic beads, and meet the separation requirements

Active Publication Date: 2022-07-22
甄融生物科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the existing problem of how to improve the separation efficiency of magnetic bead equipment

Method used

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  • A kind of control method of magnetic bead purification equipment
  • A kind of control method of magnetic bead purification equipment

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Experimental program
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Embodiment 1

[0040] Refer to the attached figure 1 -Attached figure 2 , this embodiment provides a technical solution: a control method of a magnetic bead purification device includes a purification container 100, a magnetic assembly 200 and a plurality of magnetic beads 300 arranged in the purification container 100, and the magnetic beads are doped with a certain amount of magnetic beads. Sepharose, sepharose, organic polymer particles, hydroxyapatite and various purification matrices obtained by surface modification of the basic particles, such as ion exchange chromatography packing, hydrophobic chromatography packing , reversed-phase chromatography packing, metal chelate chromatography packing, affinity chromatography packing, hydroxyapatite chromatography packing, etc., used to capture special macromolecular substances in solution. Disposing the magnetic assembly 200 in the purification container 100 is beneficial for the magnetic assembly 200 to directly control the movement of the...

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Abstract

The invention relates to the technical field of magnetic bead purification and separation, in particular to a control method of a magnetic bead purification device, comprising a purification container, a magnetic assembly and a plurality of magnetic beads arranged in the purification container, and the magnetic assembly includes an odd-numbered electromagnetic group and an even-numbered electromagnetic group alternately arranged. The electromagnetic group, the purification container is filled with flowing solution, and the magnetic beads are controlled to move back and forth between the even electromagnetic group and the odd electromagnetic group through the alternating magnetic properties of the odd electromagnetic group and the even electromagnetic group. The magnetic beads are fully and uniformly combined with the target molecules in the solution and the material to be separated, and at the same time, the shortcomings of insufficient binding and elution caused by the influence of surface tension in the batch process of the magnetic beads are avoided; at the same time, the device can be enlarged in parallel. Without affecting the separation effect, it can solve the separation requirements of continuous magnetic separation of large-volume materials.

Description

technical field [0001] The invention belongs to the technical field of magnetic bead purification and separation, in particular to a control method of a magnetic bead purification device. Background technique [0002] At present, the widely used magnetic bead separation method: place a common centrifuge tube on a magnetic centrifuge tube holder, put the sample into the centrifuge tube, and put the centrifuge tube into the magnetic centrifuge tube holder. Due to the limited capacity of the centrifuge tubes, large volumes of samples cannot be processed. If the capacity of the centrifuge tube is enlarged, it is easy to cause the aggregation of magnetic beads and affect the adsorption effect of the sample. [0003] In the field of biological product separation, in the amplification and production stages, to process large-capacity samples, the conventional magnetic bead separation method cannot meet its application, and must be divided into many small parts for separate processi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B03C1/02
CPCB03C1/02
Inventor 王济源樊敏娣石建国林盛泓
Owner 甄融生物科技(上海)有限公司