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Method, device and equipment for separating magnetic particles

A technology of magnetic particles and equipment, applied in the field of separation of magnetic particles, can solve the problems of ineffective improvement of detection efficiency, cumbersome and other problems

Pending Publication Date: 2021-07-16
陈琪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Enzyme-linked immunosorbent technology, chemiluminescence technology, magnetic particle chemiluminescence technology, electrochemical immunoassay technology, and mass spectrometry detection technology, which are widely used or appearing on the market, can carry out batch detection, but the antigens formed on the magnetic nanospheres need to be Antibody immune complexes or other target captures are separated from other substances in the liquid and go through a tedious washing process, so that the detection efficiency cannot be effectively improved

Method used

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  • Method, device and equipment for separating magnetic particles
  • Method, device and equipment for separating magnetic particles
  • Method, device and equipment for separating magnetic particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] In Example 1, the magnetic particles were accelerated by increasing current.

[0068] 22 induction coils are provided in the inlet catheter segment, the spiral catheter section, the exit catheter section, and the receiving platform, and the induction coil is labeled "L1, L2, L3, L4, L5, ..., L20, L21, L22", each induction. The number of turns in the coil is all set to 50 turns, and the arrangement of the induction coil is opposite the opposite direction (reference Figure 5 As shown), the induced current intensity is designed as "I1 = 2A, I2 = 4a, i3 = 6a, i4 = 8a, i5 = 10a, i20 = 40a, i21 = 42a, i22 = 44a".

[0069]During use, the first container containing a solution containing magnetic particles is placed below inlet 11, and "L1, L2, L3, L4, L4, ..., L20, L21, L22" 22 in the apparatus separating magnetic particles will be separated. A sensing coil is powered by a pulse, and the magnetic field strength generated under the induction current is: E1 <E2 <E2 <E22, under magnet...

Embodiment 2

[0071] In Embodiment 2, the magnetic particles are accelerated by sequentially increasing the number of turns of the induction coil.

[0072] 22 induction coils are provided in the inlet catheter segment, the spiral catheter section, the exit catheter, and the receiving platform, and the induction coil is marked as "L1, L2, L3, L4, L5, ..., L20, L21, L22", each induction. The current size design in the coil is 10A, and the arrangement of the connected induction coil is in the same polarity. Figure 6 As shown), the number of turns in the induction coil is designed as "S1 = 50 =, S2 = 80, S3 = 110, S4 = 140, S5 = 170, ..., I20 = 620, I21 = 650, i22 = 680 ".

[0073] During use, the first container of the solution containing magnetic particles is placed below the inlet 11, and "L1, L2, L3, L4, L5, ..., L20, L21, L22" designed in the apparatus of the separation magnetic particles are separated. 22 sensing coils were powered by pulse, and the magnetic field strength generated under the...

Embodiment 3

[0075] In Example 3, the number of induced coil turns at the same time and the current intensity in the induction coil were added to accelerate the magnetic particles.

[0076] Two2 induction coils are provided in the inlet conduit, the spiral catheter, the exit catheter, and the receiving platform, and the induction coil is labeled "L1, L2, L3, L4, L5, ..., L20, L21, L22", induction coil. The number of turns of the coil "S1 = 50, S2 = 80, S3 = 110, S4 = 140, S5 = 170 =, ..., I20 = 620, I21 = 650, I22 = 680", connected The setting of the induction coil is opposite the opposite direction (reference Figure 5 As shown), the induced current intensity is designed as "I1 = 2A, I2 = 4a, i3 = 6a, i4 = 8a, i5 = 10a, i20 = 40a, i21 = 42a, i22 = 44a".

[0077] During use, the first container of the solution containing magnetic particles is placed below the inlet 11, and "L1, L2, L3, L4, L5, ..., L20, L21, L22" designed in the apparatus of the separation magnetic particles are separated. 22 s...

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Abstract

The invention relates to a method, a device and equipment for separating magnetic particles. The device comprises a tubular passage through which the magnetic particles can flow and a magnetic field applying unit, wherein the tubular passage comprises an inlet and an outlet, the inlet can be in butt joint with a first container containing a solution containing the magnetic particles, and the outlet can be in butt joint with a second container receiving the magnetic particles; the magnetic field applying unit is configured to apply a magnetic field to form a magnetic force in an axial direction of the tubular passage; the magnetic force can suck out the magnetic particles from the solution in the first container such as a reaction cup, and the magnetic particles are sucked into the tubular passage through the inlet, flow through the tubular passage and are discharged to the second container from the outlet. According to the invention, magnetic particle separation is realized. Compared with the prior art, rapid online separation is achieved, and cleaning is avoided.

Description

Technical field [0001] The present application relates to the field of magnetic particulate separation, and more particularly to a method, apparatus, and apparatus for separating magnetic particles. Background technique [0002] At present, a large number of enzyme-linked immunization technologies, chemiluminescence techniques, magneto-micropaste chemiluminescence techniques, electrochemical immunoassay techniques, and mass spectrometry techniques can be carried out, but the antigen formed by magnetic nano-microspheres is required for bulk detection. Antibody immune complex or other target capture is separated from other substances in the liquid, through a cumbersome washing process, so that the detection efficiency is less effective. Inventive content [0003] In order to solve the above technical problems or at least partially solve the above technical problems, the present application provides a method, apparatus, and apparatus for separating magnetic particles. [0004] In t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543
CPCG01N33/54326
Inventor 不公告发明人
Owner 陈琪