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Application of EphA2 gene in preparation of product for treating or diagnosing breast cancer caused by pyroptosis-related protein

A related protein and breast cancer technology, applied in the field of biomedicine, can solve the problems of difficult to obtain breast cancer drugs, time-consuming and other problems, and achieve the effect of treating invasive breast cancer, inhibiting proliferation, and increasing the level of pyroptosis

Pending Publication Date: 2021-07-23
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical diagnosis of invasive breast cancer is still based on pathological samples. HE staining is used to analyze whether the tissue is invasive breast cancer. Access to drug for pyroptosis-associated protein-associated breast cancer

Method used

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  • Application of EphA2 gene in preparation of product for treating or diagnosing breast cancer caused by pyroptosis-related protein
  • Application of EphA2 gene in preparation of product for treating or diagnosing breast cancer caused by pyroptosis-related protein
  • Application of EphA2 gene in preparation of product for treating or diagnosing breast cancer caused by pyroptosis-related protein

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Correlation analysis between EphA2 and NLRP3, Caspase1 and IL-1β in breast cancer tissues

[0035] 1. Experimental objects: 42 breast cancer, paracancerous tissue and normal breast tissue specimens were collected from the Third Department of Oncology, Cancer Hospital, General Hospital of Ningxia Medical University. The pathological type was invasive breast cancer, the experiment was approved by the hospital ethics committee, and the patient’s informed consent was obtained

[0036] 2. Instrument materials and reagents

[0037] Main instruments: ultra-clean workbench (Antai); 5415D micro-centrifuge (Eppendorf); BS110S precision balance (Sartorius); vertical electrophoresis apparatus and Model 680 automatic microplate reader (Bio-Rad); homogenizer ( MPBiomedicals); Confocal Laser Microscopy (Zeiss);

[0038] Main reagents: protein extraction kit and protein quantification kit (Nanjing, KGI); EphA2 and ICAM1 antibodies (Jiangsu, Affinity); Caspase1, NLRP3 and IL-1β ant...

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Abstract

The invention relates to the technical field of biological medicines, and particularly discloses application of an EphA2 gene in preparation of a product for treating or diagnosing breast cancer caused by pyroptosis-related protein, the pyroptosis level in breast cancer tissues is reduced, the expression of EphA2 in the breast cancer tissues is increased, and the EphA2 is in negative correlation with pyroptosis. The EphA2 gene provided by the invention is in negative correlation with the expression of NLRP3, Caspase1 and IL-1beta, and can be used for preparing a medicine for treating the invasive breast cancer by utilizing the correlation of the EphA2 gene and the expression of NLRP3, Caspase1 and IL-1beta.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the use of EphA2 gene in preparing products for treating or diagnosing breast cancer caused by pyroptosis-related proteins. Background technique [0002] Breast cancer is one of the malignant tumors with the highest cancer rate in women. Studies have found that about one in eight women in the world will suffer from breast cancer. Due to changes in living standards and improved screening conditions, the incidence of breast cancer is increasing year by year. Although surgery, hormone therapy, and molecular targeting have made remarkable progress in the treatment of breast cancer and effectively improved the treatment effect; however, there are still great obstacles and challenges in improving the efficacy and survival rate. More and more studies have shown that inflammation is closely related to the occurrence, development and metastasis of tumors. During the process of tumor ...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/68A61K45/00A61P35/00
CPCG01N33/57415G01N33/57484G01N33/74A61K45/00A61P35/00
Inventor 马胜超吴立刚姜怡邓纳丽揭育祯张晴丁宁
Owner NINGXIA MEDICAL UNIV
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