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Method for control of a bioprocess

A biological process and controller technology, applied in the fields of biochemical equipment and methods, program control, general control systems, etc., to achieve the effect of reducing computational complexity, increasing scope, and improving control

Pending Publication Date: 2021-07-23
CYTIVA SWEDEN AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This has the disadvantage of requiring the generation of an extensive dataset that can be used as a basis for the model
An additional disadvantage is that the resulting models are generally applicable with acceptable accuracy only for the exact bioprocess scale and bioreactor system in which the dataset was generated
An additional disadvantage is that the resulting models are usually only applicable with acceptable accuracy for specific time intervals or phases of the biological process

Method used

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  • Method for control of a bioprocess
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  • Method for control of a bioprocess

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Embodiment Construction

[0031] "Or" in this description and corresponding claims is to be understood as covering the mathematical OR of "and" and "or", rather than as XOR (exclusive OR). The indefinite article "a" in the present disclosure and claims is not limited to "one", but can also be understood as "one or more", ie a plurality.

[0032] In the present disclosure, the term "period" or "biological process phase" means a distinguishable phase in a biological process. In the example of a cell culture biological process, the period may be a stasis period, a LOG period or a logarithmic period and a stationary period. Cells in culture typically proliferate following standard growth patterns. The first period of growth after the culture is seeded is the stagnation period, which is a period of slow growth when the cells are acclimatized to the culture environment and ready to grow rapidly. The stasis period is followed by the LOG period (ie, the "logarithmic" period), ie, the time period in which cel...

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Abstract

The present invention relates to a computer implemented method (400) performed by a controller (C) configured to control a bioprocess comprised in a bioreactor (BR), the method comprising obtaining (410) measurement results by performing spectrophotometry of a bioprocessing fluid (FL), generating (420) control parameters based on the measurement results and one model and, controlling (430) the bioprocess using the generated parameters.

Description

technical field [0001] The present invention relates to a method for controlling biological processes. The invention further relates to controllers and systems. Background technique [0002] The biotechnology industry frequently uses bioreactors for carrying out biological processes such as the cultivation of cells. Performing a biological process generally involves controlling the flow of one or more additive fluids and / or one or more additive gases to the biological processing fluid. An example of an additive fluid may be dextrose. An example of an additive gas may be oxygen. [0003] In one example, during a typical bioprocessing manufacturing process, there is often a need to monitor process properties / bioprocessing variables in a bioprocessing fluid. For example, process properties / variables that need to be monitored may include glucose content, lactose / lactic acid content, viable cell content temperature, fluid pressure, fluid pH, fluid conductivity, and the like. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G05B17/02
CPCG05B17/02C12M41/34C12M41/44C12M41/46C12M41/48G05B19/4155G05B2219/32287C12M41/36
Inventor A·阿克森H·奥尔维克M·安蒂
Owner CYTIVA SWEDEN AB