Traditional Chinese medicine polysaccharide with anti-osteoporosis activity as well as preparation method and application thereof

A polysaccharide and traditional Chinese medicine technology, applied in the directions of organic active ingredients, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of not obtaining Phellodendron chinensis homogeneous polysaccharide, not involving the influence of Phellodendron chinensis polysaccharide, and not having functional group analysis, etc. The effect of glycation end product content, reducing trabecular bone separation and reducing damage

Active Publication Date: 2021-07-30
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the Phellodendron Phellodendri polysaccharide in this invention is a crude polysaccharide, no gel chromatography purification step is used, there are no structural characterization steps such as functional group analysis, monosaccharide composition analysis, main chain structure analysis and molecular weight analysis, and no homogeneous polysaccharide from Phellodendron Phellodendri is obtained. The Fine Structure of Phellodendron Phellodendri Polysaccharides
The effect of Phellodendron polysaccharide on diabetes and the effect of Phellodendron polysaccharide on bone microstructure were not involved in the pharmacodynamic activity research experiment

Method used

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  • Traditional Chinese medicine polysaccharide with anti-osteoporosis activity as well as preparation method and application thereof
  • Traditional Chinese medicine polysaccharide with anti-osteoporosis activity as well as preparation method and application thereof
  • Traditional Chinese medicine polysaccharide with anti-osteoporosis activity as well as preparation method and application thereof

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Embodiment 1

[0036] The present embodiment provides a kind of preparation method of traditional Chinese medicine polysaccharide, it comprises the following steps:

[0037] Step S1, preparation of Cortex Phellodendron crude polysaccharide (PCP)

[0038] In this step, adding ethanol to Phellodendron Phellodendri is crushed and extracted, and then water is used to extract the extracted residue to obtain an extract, and the obtained extract is added to ethanol for precipitation, and the obtained precipitate is the crude polysaccharide of Phellodendron Phellodendri ( PCP);

[0039] Step S2, preparing Phellodendron Phellodendron neutral polysaccharide (PCP-1)

[0040] In this step, water is used to dissolve the Phellodendron crude polysaccharide (PCP) obtained in step S1, and then trichloroacetic acid is used to remove the protein in the solution and the supernatant is collected, and then the supernatant is dialyzed, and the obtained The dialysate is chromatographically purified using a DEAE a...

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Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to traditional Chinese medicine polysaccharide with anti-osteoporosis activity and a preparation method and application thereof. Cortex phellodendri polysaccharide can be prepared by the following steps: step S1, preparing crude cortex phellodendri polysaccharide (PCP); step S2, preparing neutral cortex phellodendri polysaccharide (PCP-1); and step S3, preparing neutral homogeneous cortex phellodendri polysaccharide (PPCP-1). The traditional Chinese medicine polysaccharide can be better suitable for industrial production and has a better effect of treating diabetes and osteoporosis complicated by diabetes.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine polysaccharide with anti-osteoporosis activity and its preparation method and application. Background technique [0002] Diabetic osteoporosis is a serious complication of diabetes with a high incidence. It is characterized by osteopenia, bone microstructural damage, and easy fractures. Clinically, it is often manifested as pain, deformity, and fractures, which seriously affect the quality of life of patients. The pathogenesis of diabetic osteoporosis is mainly due to the accumulation of advanced glycation end products in bone tissue, which destroys bone homeostasis and accelerates bone loss. Large response, poor patient tolerance, uncertain curative effect and other issues. Therefore, it is urgent to find safe and effective new drugs. [0003] Phellodendron Phellodendri is the bark of Phellodendron Phellodendri, an arbor plan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61K36/756A61P3/10A61P19/10
CPCC08B37/0003C08B37/006A61K31/715A61K36/756A61P3/10A61P19/10
Inventor 王娜妮张岩许平翠
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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