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Application of forsythiaside A to preparation of anti-esophageal cancer medicine

A technology of forsythiaside and esophageal cancer, which is applied in the field of application of forsythiaside A in the preparation of anti-esophageal cancer drugs, and can solve the problems of not clearly disclosing the specific effects of FSA new Shuanghuanglian formula drugs

Active Publication Date: 2021-08-06
ZHENGZHOU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above patent application involves FSA, it does not clearly disclose the specific role of FSA in the new Shuanghuanglian formula drug that inhibits tumor proliferation and migration
Therefore, the current research on FSA as an effective anti-tumor drug has not been reported.

Method used

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  • Application of forsythiaside A to preparation of anti-esophageal cancer medicine
  • Application of forsythiaside A to preparation of anti-esophageal cancer medicine
  • Application of forsythiaside A to preparation of anti-esophageal cancer medicine

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Embodiment Construction

[0031] The technical solutions of the present invention will be described in further detail below through specific implementation methods. Unless otherwise specified, the technical means used in the following examples are conventional means well known to those skilled in the art.

[0032] The reagents and sources used in the following examples are as follows: Forsythiaside A was purchased from Chengdu Effa Biotechnology Co., Ltd., with a purity of 98%; fetal bovine serum was purchased from Israel Biological Industries; DMEM medium was purchased from Israel Biological Industries ; 0.25% trypsin was purchased from Israel Biological Industries; CCK-8 kits, cell cycle kits, and apoptosis kits were purchased from Shanghai Biyuntian Biotechnology Co., Ltd.; DMSO (dimethyl sulfoxide) was purchased from the United States Sigma-Aldrich Company; 4% paraformaldehyde, crystal violet staining solution, PBS phosphate buffer saline, and alcohol were purchased from Shanghai Sangon Bioengineer...

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Abstract

The invention provides an application of forsythiaside A to preparation of an anti-esophageal squamous cell carcinoma medicine. The forsythiaside A is used as an active component in the anti-esophageal squamous cell carcinoma medicine, and the molecular formula of the forsythiaside A is C29H36O15. The forsythoside A mainly inhibits proliferation, clone formation and cell migration of esophageal squamous carcinoma cells, or promotes apoptosis of the esophageal squamous carcinoma cells by retarding the cycle of the esophageal squamous carcinoma cells so as to achieve the purpose of resisting the esophageal squamous carcinoma. Therefore, the forsythiaside A has an inhibiting effect on the malignant phenotype of the esophageal squamous carcinoma.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of forsythiaside A in the preparation of anti-esophageal cancer drugs. Background technique [0002] Esophageal cancer is the most common malignant tumor of the digestive tract, one of the six most lethal tumors in the world, and ranks fourth in cancer mortality in my country. According to histological type, esophageal cancer is divided into esophageal squamous cell carcinoma and esophageal adenocarcinoma, among which, esophageal squamous cell carcinoma is the main pathological type. The incidence of esophageal cancer in my country is increasing year by year, and new cases in my country account for more than half of the new cases of esophageal cancer in the world, and Linzhou City in Anyang, Henan Province is a high-incidence area for esophageal cancer. Since early esophageal cancer has no specific clinical symptoms, most patients with esophageal cancer are already in ...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P35/00A61K36/634
CPCA61K31/7032A61P35/00A61K36/634
Inventor 杨莹莹邓培渊杨玉珍
Owner ZHENGZHOU NORMAL UNIV
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