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Application of forsythiaside a in the preparation of anti-esophageal squamous cell carcinoma drugs

A technology for esophageal squamous cell carcinoma and forsythiaside, applied in the field of biomedicine, can solve the problem of not clearly disclosing the specific effect of FSA new Shuanghuanglian formula drug and the like

Active Publication Date: 2022-04-22
ZHENGZHOU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above patent application involves FSA, it does not clearly disclose the specific role of FSA in the new Shuanghuanglian formula drug that inhibits tumor proliferation and migration
Therefore, the current research on FSA as an effective anti-tumor drug has not been reported.

Method used

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  • Application of forsythiaside a in the preparation of anti-esophageal squamous cell carcinoma drugs
  • Application of forsythiaside a in the preparation of anti-esophageal squamous cell carcinoma drugs
  • Application of forsythiaside a in the preparation of anti-esophageal squamous cell carcinoma drugs

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Embodiment Construction

[0031] The technical solutions of the present invention will be described in further detail below through specific implementation methods. Unless otherwise specified, the technical means used in the following examples are conventional means well known to those skilled in the art.

[0032] The reagents and sources used in the following examples are as follows: Forsythiaside A was purchased from Chengdu Effa Biotechnology Co., Ltd., with a purity of 98%; fetal bovine serum was purchased from Israel Biological Industries; DMEM medium was purchased from Israel Biological Industries; 0.25 % trypsin was purchased from Biological Industries of Israel; CCK-8 kits, cell cycle kits, and apoptosis kits were purchased from Shanghai Biyuntian Biotechnology Co., Ltd.; DMSO (dimethyl sulfoxide) was purchased from Sigma-Aldrich, USA Company; 4% paraformaldehyde, crystal violet staining solution, PBS phosphate buffer saline, and alcohol were purchased from Shanghai Sangon Bioengineering Co., L...

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Abstract

The invention provides an application of forsythiaside A in the preparation of an anti-esophageal cancer drug, wherein, forsythiaside A is used as an active ingredient in the anti-esophageal squamous cell carcinoma drug, and its molecular formula is C 29 h 36 o 15 . Forsythiaside A mainly achieves the purpose of anti-esophageal squamous cell carcinoma by inhibiting the proliferation, colony formation, and cell migration of esophageal squamous cell carcinoma cells, or by blocking the cycle of esophageal squamous cell carcinoma cells and promoting the apoptosis of esophageal squamous cell carcinoma cells; therefore, even Arthrin A inhibits the malignant phenotype of esophageal squamous cell carcinoma.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of forsythiaside A in the preparation of anti-esophageal squamous cell carcinoma drugs. Background technique [0002] Esophageal cancer is the most common malignant tumor of the digestive tract, one of the six most lethal tumors in the world, and ranks fourth in cancer mortality in my country. According to histological type, esophageal cancer is divided into esophageal squamous cell carcinoma and esophageal adenocarcinoma, among which, esophageal squamous cell carcinoma is the main pathological type. The incidence of esophageal cancer in my country is increasing year by year, and new cases in my country account for more than half of the new cases of esophageal cancer in the world, and Linzhou City in Anyang, Henan Province is a high-incidence area for esophageal cancer. Since early esophageal cancer has no specific clinical symptoms, most patients with esophageal cance...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7032A61P35/00A61K36/634
CPCA61K31/7032A61P35/00A61K36/634
Inventor 杨莹莹邓培渊杨玉珍
Owner ZHENGZHOU NORMAL UNIV
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